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[F-18]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of beta-amyloid fibrils

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dc.contributor.authorLee, Ji Hoon-
dc.contributor.authorByeon, Seong Rim-
dc.contributor.authorKim, YoungSoo-
dc.contributor.authorLim, Soo Jeong-
dc.contributor.authorOh, Seung Jun-
dc.contributor.authorMoon, Dae Hyuk-
dc.contributor.authorYoo, Kyung Ho-
dc.contributor.authorChung, Bong Young-
dc.contributor.authorKim, Dong Jin-
dc.date.accessioned2021-09-09T03:37:55Z-
dc.date.available2021-09-09T03:37:55Z-
dc.date.created2021-06-10-
dc.date.issued2008-10-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/122559-
dc.description.abstractIn this study a novel series of isoindol-1-one and isoindol-1,3-dione derivatives for beta-amyloid-specific binding agents is described. Twelve compounds were synthesized and evaluated via a competitive binding assay with [I-125]TZDM against beta-amyloid 1-42 (A beta 42) aggregates. Two new [F-18]-labeled isoindole derivatives were synthesized and evaluated as potential beta-amyloid imaging probes based on the in vivo pharmacokinetic profiles. The preliminary results suggest that these [F-18]18b and [F-18]18c are promising positron emission tomography (PET) imaging probes for studying accumulation of A beta fibrils in the brains of Alzheimer's disease (AD) patients. (C) 2008 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectALZHEIMERS-DISEASE-
dc.subjectNEUROFIBRILLARY TANGLES-
dc.subjectPLAQUES-
dc.subjectMEDICINE-
dc.subjectBINDING-
dc.title[F-18]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of beta-amyloid fibrils-
dc.typeArticle-
dc.contributor.affiliatedAuthorChung, Bong Young-
dc.identifier.doi10.1016/j.bmcl.2008.05.019-
dc.identifier.scopusid2-s2.0-53549126618-
dc.identifier.wosid000259972800083-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.20, pp.5701 - 5704-
dc.relation.isPartOfBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume18-
dc.citation.number20-
dc.citation.startPage5701-
dc.citation.endPage5704-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusALZHEIMERS-DISEASE-
dc.subject.keywordPlusNEUROFIBRILLARY TANGLES-
dc.subject.keywordPlusPLAQUES-
dc.subject.keywordPlusMEDICINE-
dc.subject.keywordPlusBINDING-
dc.subject.keywordAuthorAlzheimer&apos-
dc.subject.keywordAuthors disease-
dc.subject.keywordAuthor[F-18]-labeled-
dc.subject.keywordAuthorPET-
dc.subject.keywordAuthorimaging probe-
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