IL-18 enhances ULBP2 expression through the MAPK pathway in leukemia cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Hyunkeun | - |
dc.contributor.author | Kim, Yung-Eun | - |
dc.contributor.author | Hur, Daeyoung | - |
dc.contributor.author | Lim, Jong-Seok | - |
dc.contributor.author | Yang, Young | - |
dc.contributor.author | Cho, Byung Joo | - |
dc.contributor.author | Kim, Cherl-hyun | - |
dc.contributor.author | Kim, Taesung | - |
dc.contributor.author | Bang, Saic | - |
dc.contributor.author | Lee, Wang Jae | - |
dc.contributor.author | Park, Hyunjeong | - |
dc.contributor.author | Cho, DaeHo | - |
dc.date.accessioned | 2021-09-09T04:14:06Z | - |
dc.date.available | 2021-09-09T04:14:06Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-09-30 | - |
dc.identifier.issn | 0165-2478 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122688 | - |
dc.description.abstract | Expression of UL16-binding proteins (ULBPs) has been reported in various cancers, such as leukemia and melanoma, and also in some other cancer cell lines. However, the factors that modulate the expression of ULBPs are not well defined. In this study, we investigated the effects of IL-18 on the expression of NKG2D ligands in leukemia cells. IL-18 treatment increased ULBP2 expression in leukemia cells at the mRNA and protein levels. In addition, PD98059 (an ERK1/2 MAPK inhibitor) and SP600125 (a JNK inhibitor) attenuated IL-18-induced ULBP2 expression in a dose-dependent manner. We observed that ERK1/2 and JNK MAPK phosphorylation increased upon treatment with IL-18. IL-18 elevated CD107a expression in cancer cells and increased the cytotoxic activity of NK cells; therefore, we propose that IL-18 increases the susceptibility of target cells by inducing surface expression of ULBP2. Taken together, these findings suggest that IL-18 may play a critical role in regulating ULBP2 expression via the ERK1/2 and JNK MAPK pathways in leukemia cells. (C) 2008 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | NATURAL-KILLER-CELLS | - |
dc.subject | I-RELATED MOLECULES | - |
dc.subject | NKG2D RECEPTOR | - |
dc.subject | T-CELLS | - |
dc.subject | GLYCOPROTEIN UL16 | - |
dc.subject | GAMMA PRODUCTION | - |
dc.subject | NK CELLS | - |
dc.subject | CYTOTOXICITY | - |
dc.subject | LIGANDS | - |
dc.subject | SUSCEPTIBILITY | - |
dc.title | IL-18 enhances ULBP2 expression through the MAPK pathway in leukemia cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Taesung | - |
dc.identifier.doi | 10.1016/j.imlet.2008.07.007 | - |
dc.identifier.scopusid | 2-s2.0-50449084622 | - |
dc.identifier.wosid | 000260160800015 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGY LETTERS, v.120, no.1-2, pp.103 - 107 | - |
dc.relation.isPartOf | IMMUNOLOGY LETTERS | - |
dc.citation.title | IMMUNOLOGY LETTERS | - |
dc.citation.volume | 120 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 103 | - |
dc.citation.endPage | 107 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | NATURAL-KILLER-CELLS | - |
dc.subject.keywordPlus | I-RELATED MOLECULES | - |
dc.subject.keywordPlus | NKG2D RECEPTOR | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | GLYCOPROTEIN UL16 | - |
dc.subject.keywordPlus | GAMMA PRODUCTION | - |
dc.subject.keywordPlus | NK CELLS | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | LIGANDS | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordAuthor | IL-18 | - |
dc.subject.keywordAuthor | Natural killer cells | - |
dc.subject.keywordAuthor | Tumor immunity | - |
dc.subject.keywordAuthor | ULBP | - |
dc.subject.keywordAuthor | NKG2D | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.