TIMP1 induces CD44 expression and the activation and nuclear translocation of SHP1 during the late centrocyte/post-germinal center B cell differentiation
DC Field | Value | Language |
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dc.contributor.author | Kim, Young-Sik | - |
dc.contributor.author | Seo, Dong-Wan | - |
dc.contributor.author | Kong, Su-Kang | - |
dc.contributor.author | Lee, Ju-Han | - |
dc.contributor.author | Lee, Eung-Seok | - |
dc.contributor.author | Stetler-Stevenson, Maryalice | - |
dc.contributor.author | Stetler-Stevenson, William G. | - |
dc.date.accessioned | 2021-09-09T04:15:10Z | - |
dc.date.available | 2021-09-09T04:15:10Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-09-28 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122694 | - |
dc.description.abstract | Tissue inhibitor of metalloproteinase-1 (TIMP1) is a survival factor of germinal center (GC) B cells, and its over-expression is correlated with aggressive B cell lymphomas and classical Hodgkin lymphomas. We previously demonstrated that TIMP1 down-regulates B-cell receptor and BCL6, and activates interleukins-6,-10 (ILs)/signal transducer and activator of transcription-3 (STAT3) signaling in GC B cells. The activation of ILs/STAT3 signaling can amplify CD44 function, and vice versa, and induce protein-tyrosine phosphatase SHP1 activity by a negative feedback mechanism. Here, we show that TIMP1 up-regulates cell surface CD44 (standard and variants 3 and 7-10) and induces the activity and nuclear localization of SHP1 in an Epstein Barr virus (EBV)-negative Burkitt lymphoma cell line, the neoplastic counterpart of GC centroblasts. These results suggest that TIMP1 functions as a differentiating and survival factor of GC B cells by modulating CD44 and SHP1 in the late centrocyte/post-GC stage, regardless of EBV infection. (C) 2008 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | TYROSINE-PHOSPHATASE SHP-1 | - |
dc.subject | EPSTEIN-BARR-VIRUS | - |
dc.subject | TISSUE INHIBITOR | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | LYMPHOPROLIFERATIVE DISORDERS | - |
dc.subject | METALLOPROTEINASES-1 TIMP-1 | - |
dc.subject | TUMOR INVASION | - |
dc.subject | MYELOMA CELLS | - |
dc.subject | LYMPHOMAS | - |
dc.subject | MIGRATION | - |
dc.title | TIMP1 induces CD44 expression and the activation and nuclear translocation of SHP1 during the late centrocyte/post-germinal center B cell differentiation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young-Sik | - |
dc.contributor.affiliatedAuthor | Lee, Ju-Han | - |
dc.contributor.affiliatedAuthor | Lee, Eung-Seok | - |
dc.identifier.doi | 10.1016/j.canlet.2008.04.020 | - |
dc.identifier.scopusid | 2-s2.0-49349106411 | - |
dc.identifier.wosid | 000259847100005 | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, v.269, no.1, pp.37 - 45 | - |
dc.relation.isPartOf | CANCER LETTERS | - |
dc.citation.title | CANCER LETTERS | - |
dc.citation.volume | 269 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 37 | - |
dc.citation.endPage | 45 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | TYROSINE-PHOSPHATASE SHP-1 | - |
dc.subject.keywordPlus | EPSTEIN-BARR-VIRUS | - |
dc.subject.keywordPlus | TISSUE INHIBITOR | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | LYMPHOPROLIFERATIVE DISORDERS | - |
dc.subject.keywordPlus | METALLOPROTEINASES-1 TIMP-1 | - |
dc.subject.keywordPlus | TUMOR INVASION | - |
dc.subject.keywordPlus | MYELOMA CELLS | - |
dc.subject.keywordPlus | LYMPHOMAS | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordAuthor | TIMP1 | - |
dc.subject.keywordAuthor | CD44 | - |
dc.subject.keywordAuthor | SHP1 | - |
dc.subject.keywordAuthor | Hodgkin lymphoma | - |
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