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Electrochemical aptamer-based biosensors

Authors
Kim, Yeon SeokLee, Su JinGu, Man Bock
Issue Date
20-9월-2008
Publisher
KOREAN BIOCHIP SOCIETY-KBCS
Keywords
aptamer; biosensor; aptasensor; electrochemical; signal amplification
Citation
BIOCHIP JOURNAL, v.2, no.3, pp.175 - 182
Indexed
SCIE
SCOPUS
Journal Title
BIOCHIP JOURNAL
Volume
2
Number
3
Start Page
175
End Page
182
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/122699
ISSN
1976-0280
Abstract
Aptamers are newly emerged sensing elements that are competitive with or sometimes even better than antibodies due to their various advantages: a compact size, cost effectiveness, chemical stability, in vitro synthesis, easy modification, labeling and so on. Therefore, there have recently been intensive advances in aptamer-based biosensors including electrochemical aptasensors that are more proper to the miniaturization and integration of biosensors for high-throughput analysis and point-of-care (POC). In this review, we have summarized new state of the art strategies for an aptamer-based electrochemical sensing platform and manners of signal amplification in the categories of simple label-free electrochemical detection, electrochemical signal amplification using enzymes or nanoparticles, target-induced conformational changes, and displacement formats.
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