Serum BAFF predicts prognosis better than APRIL in diffuse large B-cell lymphoma patients treated with rituximab plus CHOP chemotherapy
- Authors
- Kim, Seok Jin; Lee, Seung Jin; Choi, In Young; Park, Yong; Choi, Chul Won; Kim, In Sun; Yu, Woosung; Hwang, Hee Sang; Kim, Byung Soo
- Issue Date
- 9월-2008
- Publisher
- WILEY
- Keywords
- BAFF; APRIL; diffuse large B-cell lymphoma; rituximab
- Citation
- EUROPEAN JOURNAL OF HAEMATOLOGY, v.81, no.3, pp.177 - 184
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF HAEMATOLOGY
- Volume
- 81
- Number
- 3
- Start Page
- 177
- End Page
- 184
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/122826
- DOI
- 10.1111/j.1600-0609.2008.01099.x
- ISSN
- 0902-4441
- Abstract
- Objectives: B-cell activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) regulate survival and proliferation of B cells. Thus the association of elevated serum levels of BAFF and APRIL with worse prognosis has been suggested in B-cell lymphoid malignancies. However, the prognostic relevance of BAFF and APRIL is unknown in patients treated with rituximab, a monoclonal antibody targeting B-cell depletion.Methods: We measured serum levels of BAFF and APRIL by enzyme-linked immunosorbent assay in 66 patients newly diagnosed as diffuse large B-cell lymphoma (DLBCL). All patients were treated with rituximab-CHOP chemotherapy.Results: The mean (+/- standard deviation) serum level of BAFF (1 970.21 +/- 1 979.45 pg/mL) was higher in DLBCL than in controls (861.03 +/- 194.92 pg/mL, Mann-Whitney U-test, P < 0.001). When the patients were dichotomized into high and low BAFF group based on the median value (1 258.00 pg/mL), high BAFF group had less numbers of complete responders to rituximab-CHOP, and more relapses or progression after or during treatment. In multivariate analysis, serum BAFF was an independent prognostic factor for overall survival and progression-free survival (P < 0.05). Although serum levels of APRIL was also higher than controls (10.60 +/- 19.08 ng/mL vs. 1.10 +/- 0.30 ng/mL, P = 0.023), it failed to show prognostic significance.Conclusions: Serum BAFF may be a useful indicator predicting prognosis in DLBCL patients treated with rituximab-containing chemotherapy.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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