Effects of hydrophilic and lipophilic beta-sitosterol derivatives on cholesterol absorption and plasma cholesterol levels in rats
DC Field | Value | Language |
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dc.contributor.author | Chung, Dae-Won | - |
dc.contributor.author | Kim, Won-Dai | - |
dc.contributor.author | Noh, Seung Kwon | - |
dc.contributor.author | Dong, Mi-Sook | - |
dc.date.accessioned | 2021-09-09T05:09:40Z | - |
dc.date.available | 2021-09-09T05:09:40Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-08-13 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122861 | - |
dc.description.abstract | The effects of two phytosterol derivatives of beta-sitosterol, a lipophilic derivative (LPSS) and a hydrophilic derivative (HPSS), on cholesterol uptake and blood lipoprotein levels in rats were compared with those of beta-sitosterol. LPSS and HPSS have solubilities of up to 0.05 g/mL in edible oil and 0.15 g/mL in water at 25 degrees C, respectively. The intragastric administration of either 30 or 50 mg of phytosterols with 10 mg of [4-C-14]-cholesterol per kg of body weight once a day for 3 consecutive days reduced cholesterol uptake by approximately 30% compared to controls that received cholesterol alone. Feeding a cholesterol-enriched diet containing 1% or 3% beta-sitosterol, LPSS, or HPSS for 2 and 4 weeks resulted in lowered levels of total blood cholesterol and reduced the atherogenic index in all groups. These results indicate that LPSS and HPSS have comparable effects to beta-sitosterol in lowering blood cholesterol levels but they differ from beta-sitosterol in having a solubility advantage. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | PLANT STANOL ESTERS | - |
dc.subject | LDL-CHOLESTEROL | - |
dc.subject | STEROL ESTERS | - |
dc.subject | PHYTOSTEROLS | - |
dc.subject | INHIBITION | - |
dc.subject | SITOSTANOL | - |
dc.subject | ESTERIFICATION | - |
dc.subject | MARGARINES | - |
dc.subject | MECHANISM | - |
dc.subject | YOGURT | - |
dc.title | Effects of hydrophilic and lipophilic beta-sitosterol derivatives on cholesterol absorption and plasma cholesterol levels in rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Dong, Mi-Sook | - |
dc.identifier.doi | 10.1021/jf8004405 | - |
dc.identifier.scopusid | 2-s2.0-50449086027 | - |
dc.identifier.wosid | 000258270300088 | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.56, no.15, pp.6665 - 6670 | - |
dc.relation.isPartOf | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 56 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 6665 | - |
dc.citation.endPage | 6670 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | PLANT STANOL ESTERS | - |
dc.subject.keywordPlus | LDL-CHOLESTEROL | - |
dc.subject.keywordPlus | STEROL ESTERS | - |
dc.subject.keywordPlus | PHYTOSTEROLS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | SITOSTANOL | - |
dc.subject.keywordPlus | ESTERIFICATION | - |
dc.subject.keywordPlus | MARGARINES | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | YOGURT | - |
dc.subject.keywordAuthor | beta-sitosterol | - |
dc.subject.keywordAuthor | hydrophilic derivative | - |
dc.subject.keywordAuthor | lipophilic derivative | - |
dc.subject.keywordAuthor | cholesterol absorption | - |
dc.subject.keywordAuthor | plasma cholesterol level | - |
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