Developmental characteristics of neuropathic pain induced by peripheral nerve injury of rats during neonatal period
DC Field | Value | Language |
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dc.contributor.author | Back, Seung Keun | - |
dc.contributor.author | Kim, Myung Ah | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Lee, Jaehee | - |
dc.contributor.author | Sung, Backil | - |
dc.contributor.author | Yoon, Youngsul | - |
dc.contributor.author | Na, Heung Sik | - |
dc.date.accessioned | 2021-09-09T05:29:20Z | - |
dc.date.available | 2021-09-09T05:29:20Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-08 | - |
dc.identifier.issn | 0168-0102 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122893 | - |
dc.description.abstract | To gain an insight into the developmental characteristics of neuropathic pain induced by peripheral nerve injury during neonatal period, we employed three groups of rats suffering from peripheral nerve injury at different postnatal times, and compared the onset time, severity and persistency of neuropathic pain behaviors, such as mechanical and cold allodynia. The first group (PO group) was subjected to partial injury of tail-innervating nerves within 24 h after birth, the second group (P10 group) underwent nerve injury at postnatal day (P) 10, and the third group (P60 group) was subjected to injury at P60. Although mechanical allodynia was readily detectable in the P60 group even 1 day after nerve injury, the signs of neuropathic pain were observed from 6 or 8 weeks after nerve injury in the PO or P 10 groups, respectively. Compared with the P60 group, the PO group showed more robust mechanical and cold allodynia, whereas the P10 group exhibited rather milder pains. In addition, while the PO and P60 groups showed long-lasting signs of mechanical allodynia, the P10 group exhibited shorter persistency. These results indicate that peripheral nerve injury during neonatal period leads to neuropathic pain with distinct developmental characteristics later in life. (C) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | REFLEX SYMPATHETIC DYSTROPHY | - |
dc.subject | BRACHIAL-PLEXUS INJURY | - |
dc.subject | GENE-RELATED PEPTIDE | - |
dc.subject | MECHANICAL ALLODYNIA | - |
dc.subject | DORSAL-HORN | - |
dc.subject | SPINAL-CORD | - |
dc.subject | POSTNATAL-DEVELOPMENT | - |
dc.subject | MODEL | - |
dc.subject | NEURONS | - |
dc.subject | SECTION | - |
dc.title | Developmental characteristics of neuropathic pain induced by peripheral nerve injury of rats during neonatal period | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Na, Heung Sik | - |
dc.identifier.doi | 10.1016/j.neures.2008.04.012 | - |
dc.identifier.scopusid | 2-s2.0-45449117072 | - |
dc.identifier.wosid | 000258054800012 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE RESEARCH, v.61, no.4, pp.412 - 419 | - |
dc.relation.isPartOf | NEUROSCIENCE RESEARCH | - |
dc.citation.title | NEUROSCIENCE RESEARCH | - |
dc.citation.volume | 61 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 412 | - |
dc.citation.endPage | 419 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | REFLEX SYMPATHETIC DYSTROPHY | - |
dc.subject.keywordPlus | BRACHIAL-PLEXUS INJURY | - |
dc.subject.keywordPlus | GENE-RELATED PEPTIDE | - |
dc.subject.keywordPlus | MECHANICAL ALLODYNIA | - |
dc.subject.keywordPlus | DORSAL-HORN | - |
dc.subject.keywordPlus | SPINAL-CORD | - |
dc.subject.keywordPlus | POSTNATAL-DEVELOPMENT | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | SECTION | - |
dc.subject.keywordAuthor | neonates | - |
dc.subject.keywordAuthor | neuropathic pain | - |
dc.subject.keywordAuthor | mechanical allodynia | - |
dc.subject.keywordAuthor | cold allodynia | - |
dc.subject.keywordAuthor | postnatal development | - |
dc.subject.keywordAuthor | peripheral neuropathy | - |
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