Lamotrigine prevents MK801-induced alterations in early growth response factor-1 mRNA levels and immunoreactivity in the rat brain
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sang-Ha | - |
dc.contributor.author | Seo, Young Ho | - |
dc.contributor.author | Moon, Bo-Hyun | - |
dc.contributor.author | Choi, Song-hyen | - |
dc.contributor.author | Kang, Seungwoo | - |
dc.contributor.author | Lee, Kuem-Ju | - |
dc.contributor.author | Choi, Sang-Hyun | - |
dc.contributor.author | Lee, Min-Soo | - |
dc.contributor.author | Chun, Boe-Gwun | - |
dc.contributor.author | Shin, Kyung-Ho | - |
dc.date.accessioned | 2021-09-09T05:53:59Z | - |
dc.date.available | 2021-09-09T05:53:59Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-07-28 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123009 | - |
dc.description.abstract | MK801 (dizocilpine) induces selective neurotoxic effects in the retrosplenial cortex, ranging from neuronal vacuolization to irreversible neurodegeneration depending on the dose administered. Although lannotrigine prevents MK801-induced neuronal vacuolization in the retrosplenial cortex 4 h after injection, it is not clear whether lamotrigine attenuates the subsequent neu rod egene ration that occurs 3-4 days later. Because early growth response factor-1 (egr-1) plays a key role in neurodegeneration and its expression is induced in the retrosplenial cortex following MK801 treatment, it is possible that lamotrigine may attenuate MIK801-induced neurodegeneration via inhibition of egr-1 expression in the retrosplenial cortex. To address this issue, we treated rats with lamotrigine (10 or 20 mg/kg) followed by MK801 (2 mg/kg) and measured changes in the levels of egr-1 mRNA and immunoreactivity, in the retrosplenial cortex and other brain regions 3 h later. We also evaluated the effects of these treatments on neurodegeneration 4 days following treatment using Fluoro-jade B staining. MK801 treatment increased egr-1 mRNA and immunoreactivity in the restrosplenial, cingulate, entorhinal and piriform cortices, but decreased levels in hippocampal subfields. These MK801 -induced changes in egr-1 expression were significantly inhibited by lamotrigine pretreatment. In addition, MK801-induced neurodegeneration in the retrosplenial cortex was partially blocked by lamotrigine pretreatment in a dose dependent manner. These results demonstrate that lamotrigine pretreatment prevents the MK801 -induced upregulation of egr-1 expression in a region-selective manner, and suggest that this effect may contribute, in part, to the attenuation of MK801 -induced neurodegeneration in the retrosplenial cortex. (C) 2008 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | IMMEDIATE-EARLY GENE | - |
dc.subject | MK-801-INDUCED NEURONAL NECROSIS | - |
dc.subject | RETROSPLENIAL CORTEX | - |
dc.subject | NERVOUS-SYSTEM | - |
dc.subject | EXPRESSION | - |
dc.subject | MK-801 | - |
dc.subject | PHENCYCLIDINE | - |
dc.subject | DEGENERATION | - |
dc.subject | ACTIVATION | - |
dc.subject | GLUTAMATE | - |
dc.title | Lamotrigine prevents MK801-induced alterations in early growth response factor-1 mRNA levels and immunoreactivity in the rat brain | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Sang-Hyun | - |
dc.contributor.affiliatedAuthor | Chun, Boe-Gwun | - |
dc.contributor.affiliatedAuthor | Shin, Kyung-Ho | - |
dc.identifier.doi | 10.1016/j.ejphar.2008.04.059 | - |
dc.identifier.scopusid | 2-s2.0-47749151023 | - |
dc.identifier.wosid | 000258628400011 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACOLOGY, v.589, no.1-3, pp.58 - 65 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.citation.title | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.citation.volume | 589 | - |
dc.citation.number | 1-3 | - |
dc.citation.startPage | 58 | - |
dc.citation.endPage | 65 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | IMMEDIATE-EARLY GENE | - |
dc.subject.keywordPlus | MK-801-INDUCED NEURONAL NECROSIS | - |
dc.subject.keywordPlus | RETROSPLENIAL CORTEX | - |
dc.subject.keywordPlus | NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MK-801 | - |
dc.subject.keywordPlus | PHENCYCLIDINE | - |
dc.subject.keywordPlus | DEGENERATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | GLUTAMATE | - |
dc.subject.keywordAuthor | early growth response factor-1 | - |
dc.subject.keywordAuthor | MK801 | - |
dc.subject.keywordAuthor | lamotrigine | - |
dc.subject.keywordAuthor | retrosplenial cortex | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.