Dexamethasone coordinately regulates angiopoietin-1 and VEGF: A mechanism of glucocorticoid-induced stabilization of blood-brain barrier
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyongbum | - |
dc.contributor.author | Lee, Jung Min | - |
dc.contributor.author | Park, Jae Sun | - |
dc.contributor.author | Jo, Sangmee Ahn | - |
dc.contributor.author | Kim, Yong-Ou | - |
dc.contributor.author | Kim, Chan-Wha | - |
dc.contributor.author | Jo, Inho | - |
dc.date.accessioned | 2021-09-09T05:57:08Z | - |
dc.date.available | 2021-09-09T05:57:08Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-07-18 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123019 | - |
dc.description.abstract | Glucocorticoids stabilize the blood-brain barrier (BBB), leading to attenuation of vasogenic brain edema. However, the action mechanism of glucocorticoids has been poorly elucidated. To elucidate the mechanism, we investigated whether dexamethasone (Dex), a synthetic glucocorticoid hormone, regulates the levels of key permeability regulating factors such as angiopoietin-1, angiopoietin-2, and vascular endothelial growth factor (VEGF) in the three types of cells comprising BBB. Dex increased the level of angiopoietin-1 mRNA and protein and decreased VEGF mRNA and protein in brain astrocytes and pericytes, but not in endothelial cells. The mRNA and protein of angiopoietin-2 were detected only in endothelial cells and not regulated by Dex. The Dex-incluced regulation of angiopoietin-1 and VEGF was inhibited by RU486, suggestive of glucocorticoid receptor mediation. The mRNA stability of angiopoietin-1 and VEGF was not changed by Dex treatment, implying that Dex increases angiopoietin-1 and decreases VEGF through transcriptional regulation. This is the first study showing the coordinate regulation of angiopoietin-1 and VEGF by glucocorticoids, suggesting a novel mechanism underlying glucocorticoids-induced stabilization of BBB. (C) 2008 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | IN-VITRO | - |
dc.subject | PHENOTYPIC HETEROGENEITY | - |
dc.subject | VASCULAR-PERMEABILITY | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | CELLS | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | RECEPTOR | - |
dc.subject | TIE2 | - |
dc.title | Dexamethasone coordinately regulates angiopoietin-1 and VEGF: A mechanism of glucocorticoid-induced stabilization of blood-brain barrier | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chan-Wha | - |
dc.identifier.doi | 10.1016/j.bbrc.2008.05.025 | - |
dc.identifier.scopusid | 2-s2.0-44649139796 | - |
dc.identifier.wosid | 000256874400043 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.372, no.1, pp.243 - 248 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 372 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 243 | - |
dc.citation.endPage | 248 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PHENOTYPIC HETEROGENEITY | - |
dc.subject.keywordPlus | VASCULAR-PERMEABILITY | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | TIE2 | - |
dc.subject.keywordAuthor | glucocorticoids | - |
dc.subject.keywordAuthor | dexamethasone | - |
dc.subject.keywordAuthor | endothelial cells | - |
dc.subject.keywordAuthor | astrocytes | - |
dc.subject.keywordAuthor | pericytes | - |
dc.subject.keywordAuthor | blood-brain barrier | - |
dc.subject.keywordAuthor | vascular endothelial growth factor | - |
dc.subject.keywordAuthor | angiopoietin-1 | - |
dc.subject.keywordAuthor | angiopoietin-2 | - |
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