AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2
DC Field | Value | Language |
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dc.contributor.author | Lee, Yeon Sook | - |
dc.contributor.author | Han, Jung Min | - |
dc.contributor.author | Son, Sung Hwa | - |
dc.contributor.author | Choi, Jin Woo | - |
dc.contributor.author | Jeon, Eun Ju | - |
dc.contributor.author | Bae, Suk-Chul | - |
dc.contributor.author | Park, Young In | - |
dc.contributor.author | Kim, Sunghoon | - |
dc.date.accessioned | 2021-09-09T06:00:11Z | - |
dc.date.available | 2021-09-09T06:00:11Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-07-04 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123035 | - |
dc.description.abstract | AIMP1 (also known as p43) is a factor associated with a macromolecular aminoacyl-tRNA synthetase (ARS) complex but also plays diverse regulatory roles in various physiological processes. Here, we report that AIMP1 negatively regulates TGF-beta signaling via stabilization of Smurf2. TGF-beta-dependent phosphorylation and nuclear localization of R-Smads, induction of target genes, and growth arrest were increased in AIMP1-deficient or -suppressed cells. In AIMP1-deficient or suppressed cells, the Smurf2 level was decreased. Various binding assays demonstrated the direction interaction of the C-terminal region of AIMP1 directly with the Smad7-binding region of Smurf2. The association of Smurf2 with Smad7 and its ubiquitination were inhibited by AIMP1, thereby protecting its autocatalytic degradation stimulated by Smad7. Thus, this work suggests the novel activity of AIMP1 as a component of negative feedback loop of TGF-beta signaling. (C) 2008 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | TRANSFER-RNA SYNTHETASE | - |
dc.subject | INTERACTING MULTIFUNCTIONAL PROTEIN | - |
dc.subject | E3 UBIQUITIN LIGASE | - |
dc.subject | MAD-RELATED PROTEIN | - |
dc.subject | P43 | - |
dc.subject | DEGRADATION | - |
dc.subject | COMPLEX | - |
dc.subject | IDENTIFICATION | - |
dc.subject | RECEPTOR | - |
dc.subject | PATHWAY | - |
dc.title | AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Young In | - |
dc.identifier.doi | 10.1016/j.bbrc.2008.04.099 | - |
dc.identifier.scopusid | 2-s2.0-43749097417 | - |
dc.identifier.wosid | 000256319100011 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.371, no.3, pp.395 - 400 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 371 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 395 | - |
dc.citation.endPage | 400 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | TRANSFER-RNA SYNTHETASE | - |
dc.subject.keywordPlus | INTERACTING MULTIFUNCTIONAL PROTEIN | - |
dc.subject.keywordPlus | E3 UBIQUITIN LIGASE | - |
dc.subject.keywordPlus | MAD-RELATED PROTEIN | - |
dc.subject.keywordPlus | P43 | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | AIMP1/p43 | - |
dc.subject.keywordAuthor | aminoacyl-tRNA synthetase | - |
dc.subject.keywordAuthor | TGF-beta | - |
dc.subject.keywordAuthor | smurf2 | - |
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