Concentrations of mitomycin C in rabbit corneal tissue and aqueous humor after topical administration
DC Field | Value | Language |
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dc.contributor.author | Song, Jong-Suk | - |
dc.contributor.author | Kim, Jun-Heon | - |
dc.contributor.author | Yang, Minho | - |
dc.contributor.author | Sul, Donggeun | - |
dc.contributor.author | Kim, Hyo-Myung | - |
dc.date.accessioned | 2021-09-09T06:27:56Z | - |
dc.date.available | 2021-09-09T06:27:56Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2006-12 | - |
dc.identifier.issn | 0277-3740 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123108 | - |
dc.description.abstract | Purpose: To study the aqueous and corneal pharmacokinetics of mitomycin C (MMC) after single topical administration to the central cornea and to evaluate the effects of different concentrations and different application times on the aqueous concentration of MMC. Methods: Mechanical epithelium debridement of the central 7.5 mm of the cornea was performed in New Zealand white rabbits, and a sponge soaked in 0.02% MMC solution was placed on the denuded corneal stroma for 2 minutes. Aqueous fluid and central corneal tissues samples were taken at 0.5, 1, 2, and 3 hours thereafter. MMC concentration of the samples was analyzed by high-performance liquid chromatography and evaluated at different exposure times (range: 15-120 seconds) and concentrations of applied MMC (range: 0.005%-0.04%). Results: Peak corneal concentration was 3.728 +/- 2.547 mu g/g at 30 minutes after topical administration. Maximum aqueous concentration was 0.380 +/- 0.038 mu g/mL at 1 hour after topical application. The aqueous concentration of MMC increased in a dose-dependent manner with increasing exposure time and application concentration. Aqueous MMC concentration increased at a higher rate with change of applied concentration than with exposure time. Conclusion: Good penetration of MMC through central bare cornea may be noxious to endothelial cells. Reducing concentration or decreasing exposure time seems a good modality to reduce potential MMC toxicity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | IN-SITU KERATOMILEUSIS | - |
dc.subject | LASER PHOTOREFRACTIVE KERATECTOMY | - |
dc.subject | IATROGENIC KERATECTASIA | - |
dc.subject | HAZE FORMATION | - |
dc.subject | PTERYGIUM | - |
dc.subject | SURGERY | - |
dc.subject | MYOPIA | - |
dc.subject | CONJUNCTIVAL | - |
dc.subject | KERATOCYTES | - |
dc.subject | MODULATION | - |
dc.title | Concentrations of mitomycin C in rabbit corneal tissue and aqueous humor after topical administration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sul, Donggeun | - |
dc.identifier.doi | 10.1097/01.ico.0000247208.93638.92 | - |
dc.identifier.wosid | 000243202600004 | - |
dc.identifier.bibliographicCitation | CORNEA, v.25, no.10, pp.S20 - S23 | - |
dc.relation.isPartOf | CORNEA | - |
dc.citation.title | CORNEA | - |
dc.citation.volume | 25 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | S20 | - |
dc.citation.endPage | S23 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.subject.keywordPlus | IN-SITU KERATOMILEUSIS | - |
dc.subject.keywordPlus | LASER PHOTOREFRACTIVE KERATECTOMY | - |
dc.subject.keywordPlus | IATROGENIC KERATECTASIA | - |
dc.subject.keywordPlus | HAZE FORMATION | - |
dc.subject.keywordPlus | PTERYGIUM | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | MYOPIA | - |
dc.subject.keywordPlus | CONJUNCTIVAL | - |
dc.subject.keywordPlus | KERATOCYTES | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordAuthor | mitomycin C | - |
dc.subject.keywordAuthor | pharmacokinetics | - |
dc.subject.keywordAuthor | aqueous concentration | - |
dc.subject.keywordAuthor | cornea | - |
dc.subject.keywordAuthor | high-performance liquid chromatography | - |
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