Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Sang-Youb | - |
dc.contributor.author | Kim, Cy-Hyun | - |
dc.contributor.author | Kim, Han-Seong | - |
dc.contributor.author | Jee, Yi-Hwa | - |
dc.contributor.author | Song, Hye-Kyoung | - |
dc.contributor.author | Lee, Mi-Hwa | - |
dc.contributor.author | Han, Kum-Hyun | - |
dc.contributor.author | Kim, Hyoung-Kyu | - |
dc.contributor.author | Kang, Young-Sun | - |
dc.contributor.author | Han, Jee-Young | - |
dc.contributor.author | Kim, Young-Sik | - |
dc.contributor.author | Cha, Dae-Ryong | - |
dc.date.accessioned | 2021-09-09T06:33:00Z | - |
dc.date.available | 2021-09-09T06:33:00Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2006-05 | - |
dc.identifier.issn | 1046-6673 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123135 | - |
dc.description.abstract | Aldosterone induces myocardial fibrosis and vascular inflammation via proinflammatory and profibrotic cytokines. The effect of spironolactone on renal inflammation and renal function was investigated in type 2 diabetic rats. For define the molecular mechanism of spironolactone, the effect of spironolactone on the synthesis of monocyte chemotactic peptide-1 (MCP-1) and its upstream transcription factor, NF-kappa B, was evaluated in cultured mesangial cells and proximal tubular cells. There were no changes in blood glucose concentration or BP after spironolactone treatment. Spironolactone treatment significantly reduced urinary albumin excretion and ameliorated glomerulosclerosis. Urinary levels of MCP-1 were significantly increased concurrently with renal expression of MCP-1, macrophage migration inhibitory factor, and macrophage infiltration. Spironolactone treatment significantly inhibited urinary excretion of MCP-1 as well as renal MCP-1 and migration inhibitory factor expression and macrophage infiltration. In addition, aldosterone induced upregulation of MCP-1 expression and NF-kappa B transcriptional activity in cultured cells, and spironolactone reduced both NF-kappa B activation and MCP-1 synthesis. Furthermore, NF-kappa B inhibition abolished aldosterone-induced MCP-1 production. Overall, these findings suggest that aldosterone-induced NF-kappa B activation leads to activation of proinflammatory cytokines, ultimately leading to renal injury in this model. These data suggest that mineralocorticoid blockade may be a potential therapeutic target in diabetic nephropathy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC NEPHROLOGY | - |
dc.subject | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | - |
dc.subject | MIGRATION INHIBITORY FACTOR | - |
dc.subject | KAPPA-B ACTIVATION | - |
dc.subject | GROWTH-FACTOR-BETA | - |
dc.subject | RENAL INJURY | - |
dc.subject | HYPERTENSIVE-RATS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | ANGIOTENSIN-II | - |
dc.subject | ALDOSTERONE | - |
dc.subject | GLOMERULONEPHRITIS | - |
dc.title | Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cha, Dae-Ryong | - |
dc.identifier.doi | 10.1681/ASN.2005111196 | - |
dc.identifier.scopusid | 2-s2.0-33646366660 | - |
dc.identifier.wosid | 000237705500020 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, v.17, no.5, pp.1362 - 1372 | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | - |
dc.citation.title | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | - |
dc.citation.volume | 17 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1362 | - |
dc.citation.endPage | 1372 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | - |
dc.subject.keywordPlus | MIGRATION INHIBITORY FACTOR | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | RENAL INJURY | - |
dc.subject.keywordPlus | HYPERTENSIVE-RATS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | ANGIOTENSIN-II | - |
dc.subject.keywordPlus | ALDOSTERONE | - |
dc.subject.keywordPlus | GLOMERULONEPHRITIS | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.