Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Combination therapy of disseminated coccidioidomycosis with caspofungin and fluconazole

Authors
Park, DWSohn, JWCheong, HJKim, WJKim, MJKim, JHShin, C
Issue Date
15-2월-2006
Publisher
BMC
Citation
BMC INFECTIOUS DISEASES, v.6
Indexed
SCIE
SCOPUS
Journal Title
BMC INFECTIOUS DISEASES
Volume
6
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/123160
DOI
10.1186/1471-2334-6-26
ISSN
1471-2334
Abstract
Background: The current recommended therapy for diffuse coccidioidal pneumonia involves initial treatment with amphotericin B deoxycholate or high-dose fluconazole, followed by an azole after clinical improvement. Amphotericin B is more frequently used as initial therapy if the patient's deterioration is rapid. Case presentation: A 31-year-old Korean male with coccidioidomycosis presented to the hospital with miliary infiltrates on chest X-ray (CXR) and skin rash on the face and trunk. Initially, the patient did not respond to amphotericin B deoxycholate therapy. However, following caspofungin and fluconazole combination therapy, the patient showed favourable radiological, serological, and clinical response. Conclusion: This appears to be the first case of diffuse coccidioidal pneumonia with skin involvement in an immunocompetent patient who was treated successfully with caspofungin and fluconazole. Combination therapy with caspofungin and fluconazole may, therefore, be an alternative treatment for diffuse coccidioidal pneumonia that does not respond to amphotericin B deoxycholate therapy.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE