Thermosensitive and mucoadhesive delivery systems of mucosal vaccines
- Authors
- Han, IK; Kim, YB; Kang, HS; Sul, D; Jung, WW; Cho, HJ; Oh, YK
- Issue Date
- 2월-2006
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- mucosal; nasal; vaginal; delivery systems; thermosensitive; mucoadhesive
- Citation
- METHODS, v.38, no.2, pp.106 - 111
- Indexed
- SCIE
SCOPUS
- Journal Title
- METHODS
- Volume
- 38
- Number
- 2
- Start Page
- 106
- End Page
- 111
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/123164
- DOI
- 10.1016/j.ymeth.2005.10.003
- ISSN
- 1046-2023
- Abstract
- Mucosal vaccination is emerging as a potential administration route for eliciting antigen-specific mucosal and systemic immunogenicity. Most mucosal vaccines have been administered in a phosphate-buffered saline vehicle that may limit the exposure of antigens to the mucosal surfaces and result in poor immunogenicity. To improve the potency of the mucosal vaccines, we have developed mucosal vaccine delivery systems that might prevent leakage and increase retention of vaccines on mucosal surfaces. Thermosensitive polymers have been used to reduce the leakage problems of nasal or vaginal vaccines, while mucoadhesive polymers have been employed to increase the mucosal contact of the vaccines. Here, we describe the formulation and delivery methods of mucosal vaccines using thermosensitive and mucoadhesive polymers. (c) 2005 Elsevier Inc. All rights reserved.
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Collections - Graduate School > Department of Medicine > 1. Journal Articles
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