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Predictors of success of repeated injections of single-dose methotrexate regimen for tubal ectopic pregnancy

Authors
Cho, GJLee, SHShin, JWLee, NWKim, TKim, HJLee, KW
Issue Date
2월-2006
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
pregnancy, ectopic; methotrexate; single-dose regimen; repeated injections
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.21, no.1, pp.86 - 89
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
21
Number
1
Start Page
86
End Page
89
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/123167
DOI
10.3346/jkms.2006.21.1.86
ISSN
1011-8934
Abstract
The purpose of this study is to evaluate predictors of success of repeated injections of methotrexate in the single-dose regimen for the treatment of tubal ectopic pregnancy. All patients who had ectopic tubal pregnancy and were treated with a single dose regimen were retrospectively identified. 126 patients were treated with methotrexate. Among them, 39 patients were adequate for this study. 33 were treated with the 2nd dose and 27 were successfully cured. Additionally, 6 who were injected with the 3rd dose were all cured as well. Therefore, in our study, the success rate for the repeated injections of methotrexate was found to be 84.6% (33/39). The mean initial beta-hCG level was significantly lower in patients who were successfully treated than in patients who failed (3915.3 +/- 3281.3 vs. 8379.7 +/- 2604.4 IU/mL, p<0.05). The success rate is 96% when the beta-hCG level is less than 6,000 IU/mL and is 58% when beta-hCG is greater than 6,000 IU/mL (0R=18.57, 95% CI 1.86-185.89). The initial beta-hCG level is the only factor that has significant meaning as predictor of success of repeated injections of methotrexate in the single-dose regimen. Repeated injections of methotrexate may be particularly effective when the initial beta-hCG level is below 6,000 IU/mL.
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