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Photopolymerized check valve and its integration into a pneumatic pumping system for biocompatible sample delivery

Authors
Kim, JeongYunBaek, JuYeoulLee, KiHwaPark, YongDooSun, KyungLee, TaeSooLee, SangHoon
Issue Date
2006
Publisher
ROYAL SOC CHEMISTRY
Citation
LAB ON A CHIP, v.6, no.8, pp.1091 - 1094
Indexed
SCIE
SCOPUS
Journal Title
LAB ON A CHIP
Volume
6
Number
8
Start Page
1091
End Page
1094
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/123185
DOI
10.1039/b606918e
ISSN
1473-0197
Abstract
In this paper, we present a simple check valve whose operation mimics that of venous valves. Our check valve has a mono-leaflet and is constructed via an in situ fabrication method inside the PDMS platform. For the smooth operation of the valve's leaflet, the elasticity and the shape of the leaflet and the lubrication between the leaflet and the channel surface are important. We used 4-hydroxybutyl acrylate (4-HBA) as an elastic and photopolymerizable leaflet material. We mixed the triton X-100 with the 4-HBA pre-polymer solution for the adequate lubrication of the leaflet. We constructed the micro-pumping system by combining two venous-like check valves with an oscillating polymeric diaphragm driven by pneumatic force, and measured the flow rate according to the change of pumping frequency. We also investigated the pump's feasibility as a delivery system of biocompatible materials by using mouse embryo fibroblast cells.
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Graduate School > Department of Biomedical Sciences > 1. Journal Articles
College of Medicine > Department of Medical Science > 1. Journal Articles
College of Health Sciences > School of Biomedical Engineering > 1. Journal Articles

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