A protective role of 27-kDa heat shock protein in glucocorticoid-evoked apoptotic cell death of hippocampal progenitor cells
DC Field | Value | Language |
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dc.contributor.author | Son, GH | - |
dc.contributor.author | Geum, D | - |
dc.contributor.author | Chung, S | - |
dc.contributor.author | Park, E | - |
dc.contributor.author | Lee, KH | - |
dc.contributor.author | Choi, S | - |
dc.contributor.author | Kim, K | - |
dc.date.accessioned | 2021-09-09T06:45:18Z | - |
dc.date.available | 2021-09-09T06:45:18Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2005-12-30 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123201 | - |
dc.description.abstract | Hippocampus is one of the most vulnerable tissues to glucocorticoid (GC). In the present study, we demonstrate that dexamethasone (DEX), a synthetic GC, induces apoptotic cell death in hippocampal progenitor HiB5 cells without any additional insult. Interestingly, expression of 27-kDa heat shock protein (HSP27) was markedly induced by DEX in time- and dose-dependent manners. This induction was dependent on the production of reactive oxygen species (ROS), suggesting that DEX-evoked oxidative damage to HiB5 cells is responsible for the HSP27 induction. To evaluate a possible role of HSP27, we generated two mutant HiB5 cell lines, in which expression of HSP27 was inhibited or enhanced by the over-expression of HSP27 cDNA with antisense or sense orientation (AS-HSP27 and S-HSP27, respectively). DEX-induced apoptotic cell population was significantly increased in AS-HSP27 HiB5 cells and evidently decreased in S-HSP27 cells. These results indicate that HSP27 protects hippocampal progenitor cells from GC-induced apoptotic cell death. (c) 2005 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | NEURONAL CELLS | - |
dc.subject | RAT-BRAIN | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | THERMAL-STRESS | - |
dc.subject | HSP27 | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | EXPRESSION | - |
dc.subject | RECEPTOR | - |
dc.subject | GLUTATHIONE | - |
dc.subject | ACTIVATION | - |
dc.title | A protective role of 27-kDa heat shock protein in glucocorticoid-evoked apoptotic cell death of hippocampal progenitor cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chung, S | - |
dc.identifier.doi | 10.1016/j.bbrc.2005.10.152 | - |
dc.identifier.scopusid | 2-s2.0-27844463120 | - |
dc.identifier.wosid | 000233815900013 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.338, no.4, pp.1751 - 1758 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 338 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1751 | - |
dc.citation.endPage | 1758 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | NEURONAL CELLS | - |
dc.subject.keywordPlus | RAT-BRAIN | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | THERMAL-STRESS | - |
dc.subject.keywordPlus | HSP27 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | HSP27 | - |
dc.subject.keywordAuthor | glucocorticoid | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | hippocampal progenitor | - |
dc.subject.keywordAuthor | HiB5 | - |
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