Voltage-gated calcium channels play crucial roles in the glutamate-induced phase shifts of the rat suprachiasmatic circadian clock
DC Field | Value | Language |
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dc.contributor.author | Kim, DY | - |
dc.contributor.author | Choi, HJ | - |
dc.contributor.author | Kim, JS | - |
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Jeong, DU | - |
dc.contributor.author | Shin, HC | - |
dc.contributor.author | Kim, MJ | - |
dc.contributor.author | Han, HC | - |
dc.contributor.author | Hong, SK | - |
dc.contributor.author | Kim, YI | - |
dc.date.accessioned | 2021-09-09T06:54:39Z | - |
dc.date.available | 2021-09-09T06:54:39Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2005-03 | - |
dc.identifier.issn | 0953-816X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123252 | - |
dc.description.abstract | The resetting of the circadian clock based on photic cues delivered by the glutamatergic retinohypothalamic tract is an important process helping mammals to function adaptively to the daily light-dark cycle. To see if the photic resetting relies on voltage-gated Ca2+ channels (VGCCs), we examined the effects of VGCC blockers on the glutamate-induced phase shifts of circadian firing activity rhythms of suprachiasmatic nucleus (SCN) neurons in hypothalamic slices. First, we found that a cocktail of amiloride, nimodipine and omega-conotoxin MVIIC (T-, L- and NPQ-type VGCC antagonists, respectively) completely blocked both phase delays and advances, which were, respectively, induced by glutamate application in early and late night. Next, we discovered that: (i) amiloride and another T-type VGCC antagonist, mibefradil, completely obstructed the delays without affecting the advances; (ii) nimodipine completely blocked the advances while having less impact on delays; and (iii) omega-conotoxin MVIIC blocked largely, if not entirely, both delays and advances. Subsequent whole-cell recordings revealed that T-type Ca2+ currents in neurons in the ventrolateral, not dorsomedial, region of the SCN were larger during early than late night, whereas L-type Ca2+ currents did not differ from early to late night in both regions. These results indicate that VGCCs play important roles in glutamate-induced phase shifts, T-type being more important for phase delays and L-type being so for phase advances. Moreover, the results point to the possibility that a nocturnal modulation of T-type Ca2+ current in retinorecipient neurons is related to the differential involvement of T-type VGCC in phase delays and advances. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | NUCLEUS | - |
dc.subject | LIGHT | - |
dc.subject | RHYTHMS | - |
dc.subject | NEURONS | - |
dc.subject | DERIVATIVES | - |
dc.subject | MODULATION | - |
dc.subject | EXPRESSION | - |
dc.subject | NIMODIPINE | - |
dc.subject | PACEMAKER | - |
dc.subject | CURRENTS | - |
dc.title | Voltage-gated calcium channels play crucial roles in the glutamate-induced phase shifts of the rat suprachiasmatic circadian clock | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, YI | - |
dc.identifier.doi | 10.1111/j.1460-9568.2005.03950.x | - |
dc.identifier.scopusid | 2-s2.0-20244390460 | - |
dc.identifier.wosid | 000227900200008 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF NEUROSCIENCE, v.21, no.5, pp.1215 - 1222 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF NEUROSCIENCE | - |
dc.citation.title | EUROPEAN JOURNAL OF NEUROSCIENCE | - |
dc.citation.volume | 21 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1215 | - |
dc.citation.endPage | 1222 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | NUCLEUS | - |
dc.subject.keywordPlus | LIGHT | - |
dc.subject.keywordPlus | RHYTHMS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | NIMODIPINE | - |
dc.subject.keywordPlus | PACEMAKER | - |
dc.subject.keywordPlus | CURRENTS | - |
dc.subject.keywordAuthor | electrophysiology | - |
dc.subject.keywordAuthor | photic resetting | - |
dc.subject.keywordAuthor | retinohypothalamic tract | - |
dc.subject.keywordAuthor | SCN | - |
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