The role of CD4(+)CD25(bright) regulatory T cells in the maintenance of pregnancy, premature rupture of membranes, and labor
DC Field | Value | Language |
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dc.contributor.author | Seol, Hyun-Joo | - |
dc.contributor.author | Oh, Min-Jeong | - |
dc.contributor.author | Lim, Ji-Eun | - |
dc.contributor.author | Jung, Nan-Hee | - |
dc.contributor.author | Yoon, Soo-Young | - |
dc.contributor.author | Kim, Hai-Joong | - |
dc.date.accessioned | 2021-09-09T07:18:22Z | - |
dc.date.available | 2021-09-09T07:18:22Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-06-30 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123348 | - |
dc.description.abstract | Purpose: The aim of this study was to evaluate the changes of the regulatory T cell subset in peripheral blood caused by gestational age and premature rupture of membranes (PROM) with or without labor to verify the role of regulatory T cells in pregnancy. Patients and Methods: We investigated regulatory T cell distribution in the peripheral blood of pregnancies during the first trimester (group I, n = 2), the second trimester (group II, n = 12), and the third trimester without PROM and labor (group III, n = 15). In addition, we evaluated pregnancies in the third trimester complicated by PROM (group IV, n = 4) and labor with no complication by PROM (Group V, n = 5). Comparisons were made with non-pregnant controls (group VI, n = 4) using flow cytometry. Results: During uncomplicated pregnancy, the CD4(+)CD25(bright) regulatory T cell population decreased with advancing gestational age (group I = 3.35 +/- 0.47, group 11 = 2.91 +/- 1.44, group III = 2.81 +/- 1.36, group VI = 2.52 +/- 0.7 1, p = NS). When we compared group IV with group III and V to evaluate the changes of the regulatory T cells with PROM, the CD4(+)D25(bright) regulatory T cell population was significantly decreased in group IV compared to group III (p=0.001) and group V (p=0.026). Conclusion: The present results revealed that the regulatory T cell population increased in early pregnancy but decreased in pregnancies complicated by PROM, indicating that regulatory T cells might be related to the maintenance of pregnancy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | YONSEI UNIV COLLEGE MEDICINE | - |
dc.subject | SPONTANEOUS-ABORTION | - |
dc.subject | TOLERANCE | - |
dc.subject | BLOOD | - |
dc.subject | PHAGOCYTES | - |
dc.subject | CYTOKINES | - |
dc.subject | DECIDUA | - |
dc.title | The role of CD4(+)CD25(bright) regulatory T cells in the maintenance of pregnancy, premature rupture of membranes, and labor | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Min-Jeong | - |
dc.contributor.affiliatedAuthor | Yoon, Soo-Young | - |
dc.contributor.affiliatedAuthor | Kim, Hai-Joong | - |
dc.identifier.doi | 10.3349/ymj.2008.49.3.366 | - |
dc.identifier.scopusid | 2-s2.0-48649102674 | - |
dc.identifier.wosid | 000257277000004 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.49, no.3, pp.366 - 371 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 49 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 366 | - |
dc.citation.endPage | 371 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.identifier.kciid | ART001250319 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | SPONTANEOUS-ABORTION | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.subject.keywordPlus | BLOOD | - |
dc.subject.keywordPlus | PHAGOCYTES | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | DECIDUA | - |
dc.subject.keywordAuthor | regulatory T cells | - |
dc.subject.keywordAuthor | pregnancy | - |
dc.subject.keywordAuthor | premature rupture of membranes | - |
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