Isoeleutherin and eleutherinol, naturally occurring selective modulators of Th cell-mediated immune responses
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Jeong-Ho | - |
dc.contributor.author | Yu, Eun Sun | - |
dc.contributor.author | Han, Ah-Reum | - |
dc.contributor.author | Nam, Joo-Won | - |
dc.contributor.author | Seo, Eun-Kyoung | - |
dc.contributor.author | Hwang, Eun Sook | - |
dc.date.accessioned | 2021-09-09T07:19:20Z | - |
dc.date.available | 2021-09-09T07:19:20Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-06-27 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123353 | - |
dc.description.abstract | Natural compounds possessing naphthopyran moiety have been attracted by their anti-bacterial, antifungal, and anti-viral activities, as well as anti-tumor activities. Although chemical structures were critical for the potential biological activities, the detailed functional mechanisms remained unclear. Here, we have studied the effects of naphthopyran derivatives (eleutherin, isoeleutherin, and eleutherinol) on T helper cell-mediated immune responses to understand the mechanisms of their anti-microbial and anti-tumor activities. The study revealed that isoeleutherin, which has 1,4-naphthoquinone ring with alpha-methyl group, selectively and specifically stimulated IFN gamma production through the activation of T-bet gene transcription, thus enhancing Th1-mediated immune responses. However, a natural naphthopyran-4-one, eleutherinol dramatically inhibited both IFN gamma and IL-2 productions during Th cell activation by Suppressing the gene transcriptions of cytokines. Therefore, we suggest that the chemical modification and chirality of naphthopyran moiety in isoeleutherin and eleutherinol may be critical for the selective modulation of T helper cell-mediated immune responses. (C) 2008 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | TOPOISOMERASE-II INHIBITION | - |
dc.subject | PYRANONAPHTHOQUINONE ANTIBIOTICS | - |
dc.subject | LINEAGE COMMITMENT | - |
dc.subject | ALPHA-LAPACHONE | - |
dc.subject | BETA-LAPACHONE | - |
dc.subject | NAPHTHOQUINONE | - |
dc.subject | DERIVATIVES | - |
dc.subject | IRIDACEAE | - |
dc.subject | SUBSETS | - |
dc.subject | HELPER | - |
dc.title | Isoeleutherin and eleutherinol, naturally occurring selective modulators of Th cell-mediated immune responses | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Jeong-Ho | - |
dc.identifier.doi | 10.1016/j.bbrc.2008.04.060 | - |
dc.identifier.scopusid | 2-s2.0-43049173714 | - |
dc.identifier.wosid | 000256049700020 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.371, no.2, pp.278 - 282 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 371 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 278 | - |
dc.citation.endPage | 282 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | TOPOISOMERASE-II INHIBITION | - |
dc.subject.keywordPlus | PYRANONAPHTHOQUINONE ANTIBIOTICS | - |
dc.subject.keywordPlus | LINEAGE COMMITMENT | - |
dc.subject.keywordPlus | ALPHA-LAPACHONE | - |
dc.subject.keywordPlus | BETA-LAPACHONE | - |
dc.subject.keywordPlus | NAPHTHOQUINONE | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | IRIDACEAE | - |
dc.subject.keywordPlus | SUBSETS | - |
dc.subject.keywordPlus | HELPER | - |
dc.subject.keywordAuthor | naphthopyran | - |
dc.subject.keywordAuthor | naphthoquinone | - |
dc.subject.keywordAuthor | eleutherin | - |
dc.subject.keywordAuthor | isoeleutherin | - |
dc.subject.keywordAuthor | eleutherinol | - |
dc.subject.keywordAuthor | IL-2 | - |
dc.subject.keywordAuthor | IFN gamma | - |
dc.subject.keywordAuthor | T helper cell | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.