Interferon-alpha enhances artemisinin-induced differentiation of HL-60 leukemia cells via a PKC alpha/ERK pathway
DC Field | Value | Language |
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dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Chun, Sang-Young | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.accessioned | 2021-09-09T07:37:07Z | - |
dc.date.available | 2021-09-09T07:37:07Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-06-10 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123385 | - |
dc.description.abstract | Interferon-alpha (IFN-alpha) has been used in the treatment of several cancers, including chronic myeloid leukemia. Artemisinin, a sesquiterpene lactone endoperoxide that exists in several medicinal plants, is a well known anti-malarial agent. We previously reported that artemisinin by itself caused a relatively low level of HL-60 cell differentiation. In this study, we investigated the effects of IFN-alpha in combination with artemisinin on cell growth and differentiation in HL-60 leukemia cells. Combination of IFN-alpha and artemisinin synergistically induced the levels of leukemia cell differentiation, although IFN-alpha by itself did not affect cell proliferation and differentiation. The increased cell differentiation by IFN-alpha and artemisinin was significantly suppressed by the inhibitors for protein kinase C (PKC), extracellular signal-regulated kinase (ERK) and jun N-terminal kinase (JNK), but not by the inhibitors for phosphatidylinositol 3-kinase (PI3-K) and p38 mitogen-activated protein kinase (MAPK). Furthermore, co-treatment with IFN-a increased levels of PKC alpha and phosphorylated ERK. Taken together, these results indicate the enhancement of artemisinin-induced HL-60 cell differentiation by IFN-a through the activation of a PKC alpha/ERK signaling pathway, and suggest a possible use of IFN-alpha and artemisinin in the treatment of leukemic diseases. (c) 2008 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | RETINOIC ACID | - |
dc.subject | ERYTHROID-DIFFERENTIATION | - |
dc.subject | 1,25-DIHYDROXYVITAMIN D-3 | - |
dc.subject | ACTIVATION | - |
dc.subject | EXPRESSION | - |
dc.subject | INDUCTION | - |
dc.subject | GROWTH | - |
dc.subject | CANCER | - |
dc.subject | DRUGS | - |
dc.title | Interferon-alpha enhances artemisinin-induced differentiation of HL-60 leukemia cells via a PKC alpha/ERK pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1016/j.ejphar.2008.03.036 | - |
dc.identifier.scopusid | 2-s2.0-44149122802 | - |
dc.identifier.wosid | 000256821800009 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACOLOGY, v.587, no.1-3, pp.65 - 72 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.citation.title | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.citation.volume | 587 | - |
dc.citation.number | 1-3 | - |
dc.citation.startPage | 65 | - |
dc.citation.endPage | 72 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | RETINOIC ACID | - |
dc.subject.keywordPlus | ERYTHROID-DIFFERENTIATION | - |
dc.subject.keywordPlus | 1,25-DIHYDROXYVITAMIN D-3 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordAuthor | differentiation | - |
dc.subject.keywordAuthor | leukemia | - |
dc.subject.keywordAuthor | interferon-alpha | - |
dc.subject.keywordAuthor | artemisinin | - |
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