Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease
DC Field | Value | Language |
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dc.contributor.author | Jo, S-K | - |
dc.contributor.author | Bajwa, A. | - |
dc.contributor.author | Awad, A. S. | - |
dc.contributor.author | Lynch, K. R. | - |
dc.contributor.author | Okusa, M. D. | - |
dc.date.accessioned | 2021-09-09T07:42:13Z | - |
dc.date.available | 2021-09-09T07:42:13Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-06 | - |
dc.identifier.issn | 0085-2538 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123412 | - |
dc.description.abstract | The major sphingolipid metabolite, sphingosine-1-phosphate (S1P), has important biological functions. S1P is the ligand for a family of five G-protein-coupled receptors with distinct signaling pathways that regulate angiogenesis, vascular maturation, immunity, chemotaxis, and other important biological pathways. Recently, clinical trials have targeted S1P receptors (S1PRs) for autoimmune diseases and transplantation and have generated considerable interest in developing additional, more selective compounds. This review summarizes current knowledge on the biology of S1P and S1PRs that forms the basis for future drug development and the treatment of kidney disease. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | PROTEIN-COUPLED RECEPTOR | - |
dc.subject | ACUTE-RENAL-FAILURE | - |
dc.subject | SPHINGOSINE 1-PHOSPHATE RECEPTORS | - |
dc.subject | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject | SMOOTH-MUSCLE-CELLS | - |
dc.subject | MULTIPLE SIGNALING PATHWAYS | - |
dc.subject | MEDIATED TISSUE PROTECTION | - |
dc.subject | HUMAN ENDOTHELIAL-CELLS | - |
dc.subject | MATURE DENDRITIC CELLS | - |
dc.subject | T-CELL | - |
dc.title | Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jo, S-K | - |
dc.identifier.doi | 10.1038/ki.2008.34 | - |
dc.identifier.scopusid | 2-s2.0-43749098568 | - |
dc.identifier.wosid | 000255897400005 | - |
dc.identifier.bibliographicCitation | KIDNEY INTERNATIONAL, v.73, no.11, pp.1220 - 1230 | - |
dc.relation.isPartOf | KIDNEY INTERNATIONAL | - |
dc.citation.title | KIDNEY INTERNATIONAL | - |
dc.citation.volume | 73 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1220 | - |
dc.citation.endPage | 1230 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTOR | - |
dc.subject.keywordPlus | ACUTE-RENAL-FAILURE | - |
dc.subject.keywordPlus | SPHINGOSINE 1-PHOSPHATE RECEPTORS | - |
dc.subject.keywordPlus | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE-CELLS | - |
dc.subject.keywordPlus | MULTIPLE SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | MEDIATED TISSUE PROTECTION | - |
dc.subject.keywordPlus | HUMAN ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | MATURE DENDRITIC CELLS | - |
dc.subject.keywordPlus | T-CELL | - |
dc.subject.keywordAuthor | FTY720 | - |
dc.subject.keywordAuthor | SEW2871 | - |
dc.subject.keywordAuthor | ischemia-reperfusion injury | - |
dc.subject.keywordAuthor | acute kidney injury | - |
dc.subject.keywordAuthor | sphingolipid | - |
dc.subject.keywordAuthor | S1P | - |
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