Effect of CYP3A5*3 genotype on the pharmacokinetics and antiplatelet effect of clopidogrel in healthy subjects
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kyoung-Ah | - |
dc.contributor.author | Park, Pil-Whan | - |
dc.contributor.author | Park, Ji-Young | - |
dc.date.accessioned | 2021-09-09T07:53:30Z | - |
dc.date.available | 2021-09-09T07:53:30Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-06 | - |
dc.identifier.issn | 0031-6970 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123463 | - |
dc.description.abstract | Objective Clopidogrel is activated by cytochrome P450 3A ( CYP3A) to generate an active metabolite that inhibits adenosine diphosphate ( ADP)- induced platelet aggregation through irreversible binding to the platelet P2Y12 receptor. The objective of this study was to assess the effect of the CYP3A5 genotype on the pharmacokinetics and antiplatelet effect of clopidogrel in healthy subjects. Methods Twenty- two healthy subjects ( CYP3A5* 1/* 1, n= 6; CYP3A5* 1/* 3, n= 8; CYP3A5* 3/* 3, n= 8) were recruited. After the administration of a loading dose of 300 mg of clopidogrel followed by 75 mg once daily for 6 days, plasma concentrations of clopidogrel and SR26334, an inactive metabolite, were measured for 24 h. The antiplatelet effect of clopidogrel was also measured, by determining the inhibition of ADP- induced platelet aggregation for 168 h, according to CYP3A5 genotype. Results Mean plasma concentration profiles of clopidogrel and SR26334 were comparable between CYP3A5 genotype groups. In addition, the CYP3A5 genotype did not affect the pharmacokinetics of either clopidogrel or SR26334. CYP3A5 genotype also did not modulate the inhibitory effect of clopidogrel on platelet aggregation. Conclusion The CYP3A5* 3 genotype plays a minor role in causing interindividual variability of the disposition of clopidogrel and its antiplatelet effect in humans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject | CYTOCHROME-P450 3A | - |
dc.subject | CYP3A5 GENOTYPE | - |
dc.subject | CLINICAL PRESENTATION | - |
dc.subject | ACTIVE METABOLITE | - |
dc.subject | PROSTATE TUMORS | - |
dc.subject | GENETIC VARIANT | - |
dc.subject | HUMAN-LIVER | - |
dc.subject | ATORVASTATIN | - |
dc.subject | POLYMORPHISM | - |
dc.title | Effect of CYP3A5*3 genotype on the pharmacokinetics and antiplatelet effect of clopidogrel in healthy subjects | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Ji-Young | - |
dc.identifier.doi | 10.1007/s00228-008-0471-0 | - |
dc.identifier.scopusid | 2-s2.0-42549112187 | - |
dc.identifier.wosid | 000255254800005 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, v.64, no.6, pp.589 - 597 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | - |
dc.citation.title | EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | - |
dc.citation.volume | 64 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 589 | - |
dc.citation.endPage | 597 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject.keywordPlus | CYTOCHROME-P450 3A | - |
dc.subject.keywordPlus | CYP3A5 GENOTYPE | - |
dc.subject.keywordPlus | CLINICAL PRESENTATION | - |
dc.subject.keywordPlus | ACTIVE METABOLITE | - |
dc.subject.keywordPlus | PROSTATE TUMORS | - |
dc.subject.keywordPlus | GENETIC VARIANT | - |
dc.subject.keywordPlus | HUMAN-LIVER | - |
dc.subject.keywordPlus | ATORVASTATIN | - |
dc.subject.keywordPlus | POLYMORPHISM | - |
dc.subject.keywordAuthor | clopidogrel | - |
dc.subject.keywordAuthor | CYP3A5*3 | - |
dc.subject.keywordAuthor | cytochrome P450 (CYP3A5) | - |
dc.subject.keywordAuthor | platelet aggregation | - |
dc.subject.keywordAuthor | SR26334 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.