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Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection
- Authors
- Yang, Jaemoon; Lim, Eun-Kyung; Lee, Hong Jae; Park, Joseph; Lee, Sang Cheon; Lee, Kwangyeol; Yoon, Ho-Geun; Suh, Jin-Suck; Huh, Yong-Min; Haam, Seungjoo
- Issue Date
- 6월-2008
- Publisher
- ELSEVIER SCI LTD
- Keywords
- magnetic nanoparticle; fluorescence; nanohybrid; cancer; cetuximab
- Citation
- BIOMATERIALS, v.29, no.16, pp.2548 - 2555
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMATERIALS
- Volume
- 29
- Number
- 16
- Start Page
- 2548
- End Page
- 2555
- ISSN
- 0142-9612
- Abstract
- Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2O4 magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines. (c) 2008 Elsevier Ltd. All rights reserved.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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