Ectopic expression of eIF4E-transporter triggers the movement of eIF4E into P-bodies, inhibiting steady-state translation but not the pioneer round of translation
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyung Chul | - |
dc.contributor.author | Cho, Hana | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.date.accessioned | 2021-09-09T08:20:34Z | - |
dc.date.available | 2021-09-09T08:20:34Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-05-16 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123532 | - |
dc.description.abstract | Nonsense-mediated mRNA decay (NMD) is the best-characterized mRNA surveillance mechanism; this process removes faulty mRNAs harboring premature termination codons (PTCs). NMD targets newly synthesized mRNAs bound by nuclear cap-binding proteins 80/20 (CBP80/20) and exon junction complex (EJC), the former of which is thought to recruit the ribosome to initiate the pioneer round of translation. After completion of the pioneer round of translation, CBP80/20 is replaced by the cytoplasmic cap-binding protein eIF4E, which mediates steady-state translation in the cytoplasm. Here, we show that overexpression of eIF4E-T preferentially inhibits cap-dependent steady-state translation, but not the pioneer round of translation. We also demonstrate that overexpression of eIF4E-T or Dcp1a triggers the movement of eIF4E into the processing bodies. These results suggest that the pioneer round of translation differs from steady-state translation in terms of ribosome recruitment. (C) 2008 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | MESSENGER-RNA TRANSLATION | - |
dc.subject | NONSENSE-MEDIATED DECAY | - |
dc.subject | CAP-BINDING PROTEIN | - |
dc.subject | BODY FORMATION | - |
dc.subject | MECHANISM | - |
dc.subject | ABUNDANCE | - |
dc.subject | OCCURS | - |
dc.subject | CELLS | - |
dc.subject | CBP80 | - |
dc.subject | UPF1 | - |
dc.title | Ectopic expression of eIF4E-transporter triggers the movement of eIF4E into P-bodies, inhibiting steady-state translation but not the pioneer round of translation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.identifier.doi | 10.1016/j.bbrc.2008.03.017 | - |
dc.identifier.scopusid | 2-s2.0-41149176379 | - |
dc.identifier.wosid | 000254864700033 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.369, no.4, pp.1160 - 1165 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 369 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1160 | - |
dc.citation.endPage | 1165 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | MESSENGER-RNA TRANSLATION | - |
dc.subject.keywordPlus | NONSENSE-MEDIATED DECAY | - |
dc.subject.keywordPlus | CAP-BINDING PROTEIN | - |
dc.subject.keywordPlus | BODY FORMATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | ABUNDANCE | - |
dc.subject.keywordPlus | OCCURS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CBP80 | - |
dc.subject.keywordPlus | UPF1 | - |
dc.subject.keywordAuthor | eIF4E-T | - |
dc.subject.keywordAuthor | eIF4E | - |
dc.subject.keywordAuthor | CBP80 | - |
dc.subject.keywordAuthor | the pioneer round of translation | - |
dc.subject.keywordAuthor | steady-state translation | - |
dc.subject.keywordAuthor | nonsense-mediated mRNA decay | - |
dc.subject.keywordAuthor | processing bodies | - |
dc.subject.keywordAuthor | internal ribosome entry site | - |
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