The CD28/HLA-DR expressions on CD4(+) T but not CD8(+) T cells are significant predictors for progression to AIDS
DC Field | Value | Language |
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dc.contributor.author | Choi, BS | - |
dc.contributor.author | Park, YK | - |
dc.contributor.author | Lee, JS | - |
dc.date.accessioned | 2021-09-09T08:47:01Z | - |
dc.date.available | 2021-09-09T08:47:01Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2002-01 | - |
dc.identifier.issn | 0009-9104 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123618 | - |
dc.description.abstract | To investigate the changes of CD28 and HLA-DR molecules on CD4(+) and CD8(+) T cells during HIV infection, we classified 130 HIV-infected Koreans into four groups by the CD4 level as follows: group I (greater than or equal to500 cells/mm(3) ), group II (201-499 cells/mm(3) ), group III (51-200 cells/mm(3) ), and group IV (less than or equal to50 cells/mm(3) ). In CD4(+) T cells, the proportion of CD28 expression decreased significantly with the CD4 level while the proportion of HLA-DR expression increased gradually. In particular, the changes of HLA-DR expressions on CD4(+) T cells were parallel to the loss of CD28 molecules from stage III to IV. However, the CD28 expression on CD8(+) T cells decreased dramatically in the early stage of HIV infection, and the sum and pattern of CD28 and HLA-DR expressions on CD8(+) T cells was stable after the first stage. Even though CD28 down-regulation on CD8(+) T cells was very severe from the early stage of HIV infection, it might not influence the survival time of HIV-infected Koreans. The sum of the CD28(+) subsets and HLA-DR subsets in each T cell was stable in all stages of disease progression. The sums of the CD28(+) subsets and HLA-DR+ subsets in CD4(+) T and CD8(+) T cells were constant as approximately 100% and 55-60% of each T cell. These results suggested that the changes of CD28/HLA-DR expressions on CD4(+) T cells were more predictable than those on CD8(+) T cells in the evaluation of the disease progression during HIV-infected periods. However, we need further studies to understand why the sum of two molecules in each T cell are constant. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | IMMUNODEFICIENCY-VIRUS TYPE-1 | - |
dc.subject | HIV-1 INFECTION | - |
dc.subject | ANTIRETROVIRAL THERAPY | - |
dc.subject | CD28 EXPRESSION | - |
dc.subject | DOWN-REGULATION | - |
dc.subject | ACTIVATION | - |
dc.subject | LYMPHOCYTES | - |
dc.subject | EXPANSION | - |
dc.subject | CYTOMEGALOVIRUS | - |
dc.subject | MARKERS | - |
dc.title | The CD28/HLA-DR expressions on CD4(+) T but not CD8(+) T cells are significant predictors for progression to AIDS | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, BS | - |
dc.identifier.doi | 10.1046/j.1365-2249.2002.01732.x | - |
dc.identifier.scopusid | 2-s2.0-0036176972 | - |
dc.identifier.wosid | 000175381600020 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL IMMUNOLOGY, v.127, no.1, pp.137 - 144 | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL IMMUNOLOGY | - |
dc.citation.title | CLINICAL AND EXPERIMENTAL IMMUNOLOGY | - |
dc.citation.volume | 127 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 137 | - |
dc.citation.endPage | 144 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | IMMUNODEFICIENCY-VIRUS TYPE-1 | - |
dc.subject.keywordPlus | HIV-1 INFECTION | - |
dc.subject.keywordPlus | ANTIRETROVIRAL THERAPY | - |
dc.subject.keywordPlus | CD28 EXPRESSION | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | EXPANSION | - |
dc.subject.keywordPlus | CYTOMEGALOVIRUS | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordAuthor | HIV | - |
dc.subject.keywordAuthor | CD4 level | - |
dc.subject.keywordAuthor | HLA-DR molecule | - |
dc.subject.keywordAuthor | CD28 molecule | - |
dc.subject.keywordAuthor | disease progression | - |
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