Secretion of adenylate kinase 1 is required for extracellular ATP synthesis in C2C12 myotubes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choo, Hyo-Jung | - |
dc.contributor.author | Kim, Bong-Woo | - |
dc.contributor.author | Kwon, Oh-Bong | - |
dc.contributor.author | Lee, Chang Seok | - |
dc.contributor.author | Choi, Jong-Soon | - |
dc.contributor.author | Ko, Young-Gyu | - |
dc.date.accessioned | 2021-09-09T09:11:01Z | - |
dc.date.available | 2021-09-09T09:11:01Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-04-30 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123714 | - |
dc.description.abstract | Extracellular ATP (exATP) has been known to be a critical ligand regulating skeletal muscle differentiation and contractibility. ExATP synthesis was greatly increased with the high level of adenylate kinase 1 (AK1) and ATP synthase beta during C2C12 myogenesis. The exATP synthesis was abolished by the knock-down of AK1 but not by that of ATP synthase beta in C2C12 myotubes, suggesting that AK1 is required for exATP synthesis in myotubes. However, membrane-bound AK1(3 was not involved in exATP synthesis because its expression level was decreased during myogenesis in spite of its localization in the lipid rafts that contain various kinds of receptors and mediate cell signal transduction, cell migration, and differentiation. Interestingly, cytoplasmic AK1 was secreted from C2C12 myotubes but not from C2C12 myoblasts. Taken together all these data, we can conclude that AK1 secretion is required for the exATP generation in myotubes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | VASCULAR ENDOTHELIAL-CELLS | - |
dc.subject | SKELETAL-MUSCLE | - |
dc.subject | SYNTHASE COMPLEX | - |
dc.subject | HDL ENDOCYTOSIS | - |
dc.subject | LIPID RAFTS | - |
dc.subject | KINASE | - |
dc.subject | SURFACE | - |
dc.subject | RAT | - |
dc.subject | RECEPTOR | - |
dc.subject | RELEASE | - |
dc.title | Secretion of adenylate kinase 1 is required for extracellular ATP synthesis in C2C12 myotubes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Young-Gyu | - |
dc.identifier.doi | 10.3858/emm.2008.40.2.220 | - |
dc.identifier.scopusid | 2-s2.0-44349158954 | - |
dc.identifier.wosid | 000255649200008 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.40, no.2, pp.220 - 228 | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 40 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 220 | - |
dc.citation.endPage | 228 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001243094 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | VASCULAR ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | SYNTHASE COMPLEX | - |
dc.subject.keywordPlus | HDL ENDOCYTOSIS | - |
dc.subject.keywordPlus | LIPID RAFTS | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordAuthor | adenosine triphosphate | - |
dc.subject.keywordAuthor | adenylate kinase 1 | - |
dc.subject.keywordAuthor | ATP synthase | - |
dc.subject.keywordAuthor | membrane microdomains | - |
dc.subject.keywordAuthor | muscle development | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.