AIMP1/p43 protein induces the maturation of bone marrow-derived dendritic cells with T helper type 1-polarizing ability
DC Field | Value | Language |
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dc.contributor.author | Kim, Eugene | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Kim, Sunghoon | - |
dc.contributor.author | Cho, Daeho | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.accessioned | 2021-09-09T10:29:26Z | - |
dc.date.available | 2021-09-09T10:29:26Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-03-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123920 | - |
dc.description.abstract | AIMP1 (ARS-interacting multifunctional protein 1), previously known as p43, was initially identified as a factor associated with a macromolecular tRNA synthetase complex. Recently, we demonstrated that AIMP1 is also secreted and acts as a novel pleiotropic cytokine. In this study, we investigated whether AIMP1 induces the activation and maturation of murine bone marrow-derived dendritic cells (DCs). AIMP1-treated DCs exhibited up-regulated expression of cell-surface molecules, including CD40, CD86, and MHC class II. Additionally, microarray analysis and RT-PCR determinations indicated that the expression of known DC maturation genes also increased significantly following treatment with AIMP1. Treatment of DCs with AIMP1 resulted in a significant increase in IL-12 production and Ag-presenting capability, and it also stimulated the proliferation of allogeneic T cells. Importantly, AIMP1-treated DCs induced activation of Ag-specific Th type 1 (Th1) cells in vitro and in vivo. AIMP1-stimulated DCs significantly enhanced the IFN-gamma production of cocultured CD4(+) T cells. Immunization of mice with keyhole limpet hemocyanin-pulsed AIMP1 DO efficiently led to Ag-specific Th1 cell responses, as determined by flow cytometry and ELISA. The addition of a neutralizing anti-IL-12 mAb to the cell cultures that had been treated with AIMP1 resulted in the decreased production of IFN-gamma, thereby indicating that AIMP1-stimulated DCs may enhance the Th1 response through increased production of IL-12 by APCs. Taken together, these results indicate that AIMP1 protein induces the maturation and activation of DCs, which skew the immune response toward a Th1 response. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.subject | TRANSFER-RNA SYNTHETASE | - |
dc.subject | CHEMOKINE RECEPTOR CXCR3 | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | ANTITUMOR IMMUNITY | - |
dc.subject | ASSOCIATING FACTOR | - |
dc.subject | IL-12 PRODUCTION | - |
dc.subject | 3RD SIGNAL | - |
dc.subject | IFN-GAMMA | - |
dc.subject | EMAP-II | - |
dc.subject | P43 | - |
dc.title | AIMP1/p43 protein induces the maturation of bone marrow-derived dendritic cells with T helper type 1-polarizing ability | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.4049/jimmunol.180.5.2894 | - |
dc.identifier.scopusid | 2-s2.0-48749115388 | - |
dc.identifier.wosid | 000256730000026 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.180, no.5, pp.2894 - 2902 | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 180 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 2894 | - |
dc.citation.endPage | 2902 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | TRANSFER-RNA SYNTHETASE | - |
dc.subject.keywordPlus | CHEMOKINE RECEPTOR CXCR3 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ANTITUMOR IMMUNITY | - |
dc.subject.keywordPlus | ASSOCIATING FACTOR | - |
dc.subject.keywordPlus | IL-12 PRODUCTION | - |
dc.subject.keywordPlus | 3RD SIGNAL | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | EMAP-II | - |
dc.subject.keywordPlus | P43 | - |
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