Cerebral blood flow changes in man by wake-promoting drug, modafinil: a randomized double blind study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Joo, Eun Peon | - |
dc.contributor.author | Tae, Woo Suk | - |
dc.contributor.author | Jung, Ki-Young | - |
dc.contributor.author | Hong, Seung Bong | - |
dc.date.accessioned | 2021-09-09T10:31:38Z | - |
dc.date.available | 2021-09-09T10:31:38Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-03 | - |
dc.identifier.issn | 0962-1105 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123932 | - |
dc.description.abstract | To investigate the effects of a wake-promoting drug, modafinil on regional cerebral blood flow (rCBF) in healthy volunteers, we performed Tc-99m-ethylcysteinate dimer single photon emission computed tomography (SPECT) before and after modafinil or placebo administration. Twenty-one healthy subjects received single doses of 400 mg modafinil or placebo in a double blind randomized crossover study design. Administrations of modafinil or placebo in a subject were separated by a 2-week washout. Brain SPECT was performed twice before and 3 h after modafinil or placebo administration. For statistical parametric mapping analysis, all SPECT images were spatially normalized to the standard SPECT template and then smoothed using a 12mm full width at half-maximum Gaussian kernel. The paired t-test was used to compare pre- versus post-modafinil and pre- versus post-placebo SPECT images. Differences in rCBF between post-modafinil and post-placebo conditions were also tested. Modafinil decreased Epworth and Stanford sleepiness scales whereas placebo did not. The post-modafinil condition was associated with increased rCBF in bilateral thalami and dorsal pons, whereas the post-placebo condition showed increased rCBF in a smaller area of the dorsal pons when compared with the drug naive baseline condition. Compared with the post-placebo condition, the post-modafinil condition showed higher rCBF in bilateral frontopolar, orbitofrontal, superior frontal, middle frontal gyri, short insular gyri, left cingulate gyrus, left middle/inferior temporal gyri, left parahippocampal gyrus, and left pons. In healthy volunteers, modafinil increased wakefulness and rCBF in the arousal-related systems and in brain areas related to emotion and executive function. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BLACKWELL PUBLISHING | - |
dc.subject | INDUCED WAKEFULNESS | - |
dc.subject | YOUNG VOLUNTEERS | - |
dc.subject | NARCOLEPSY | - |
dc.subject | BRAIN | - |
dc.subject | RAT | - |
dc.subject | SCHIZOPHRENIA | - |
dc.subject | AMPHETAMINE | - |
dc.subject | TOMOGRAPHY | - |
dc.subject | SOMNOLENCE | - |
dc.subject | THALAMUS | - |
dc.title | Cerebral blood flow changes in man by wake-promoting drug, modafinil: a randomized double blind study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Ki-Young | - |
dc.identifier.doi | 10.1111/j.1365-2869.2008.00624.x | - |
dc.identifier.scopusid | 2-s2.0-39049121778 | - |
dc.identifier.wosid | 000253719600013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SLEEP RESEARCH, v.17, no.1, pp.82 - 88 | - |
dc.relation.isPartOf | JOURNAL OF SLEEP RESEARCH | - |
dc.citation.title | JOURNAL OF SLEEP RESEARCH | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 82 | - |
dc.citation.endPage | 88 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | INDUCED WAKEFULNESS | - |
dc.subject.keywordPlus | YOUNG VOLUNTEERS | - |
dc.subject.keywordPlus | NARCOLEPSY | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.subject.keywordPlus | AMPHETAMINE | - |
dc.subject.keywordPlus | TOMOGRAPHY | - |
dc.subject.keywordPlus | SOMNOLENCE | - |
dc.subject.keywordPlus | THALAMUS | - |
dc.subject.keywordAuthor | modafinil | - |
dc.subject.keywordAuthor | rCBF | - |
dc.subject.keywordAuthor | spect | - |
dc.subject.keywordAuthor | statistical parametric mapping | - |
dc.subject.keywordAuthor | wakefulness | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.