A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon
DC Field | Value | Language |
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dc.contributor.author | Sanchez, David Jesse | - |
dc.contributor.author | Miranda, Daniel, Jr. | - |
dc.contributor.author | Arumugaswami, Vaithilingaraja | - |
dc.contributor.author | Hwang, Seungmin | - |
dc.contributor.author | Singer, Adam E. | - |
dc.contributor.author | Senaati, Ashkon | - |
dc.contributor.author | Shahangian, Arash | - |
dc.contributor.author | Song, Moon Jung | - |
dc.contributor.author | Sun, Ren | - |
dc.contributor.author | Cheng, Genhong | - |
dc.date.accessioned | 2021-09-09T10:47:12Z | - |
dc.date.available | 2021-09-09T10:47:12Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-03 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123991 | - |
dc.description.abstract | Innate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various genomic locations to map the region of DNA that induces type I interferon. A repetitive region termed the 100-base-pair repeat region is a ligand that is both necessary and sufficient for the viral genomic DNA to induce type I interferon. A region colinear with this ligand in the genome of Kaposi's sarcoma-associated herpesvirus also induces type I interferon. We have thus defined a repetitive region of the genomes of gammaherpesviruses as the first natural DNA virus ligand that induces type I interferon. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.subject | REGULATORY FACTOR FAMILY | - |
dc.subject | TOLL-LIKE RECEPTOR-9 | - |
dc.subject | DOUBLE-STRANDED-RNA | - |
dc.subject | RIG-I | - |
dc.subject | T-CELLS | - |
dc.subject | MURINE GAMMAHERPESVIRUS-68 | - |
dc.subject | TRANSCRIPTION FACTORS | - |
dc.subject | IMMUNE-RECOGNITION | - |
dc.subject | VIRUS INTERFERENCE | - |
dc.subject | ANTIVIRAL RESPONSE | - |
dc.title | A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Moon Jung | - |
dc.identifier.doi | 10.1128/JVI.01718-07 | - |
dc.identifier.scopusid | 2-s2.0-39749095030 | - |
dc.identifier.wosid | 000253481000016 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VIROLOGY, v.82, no.5, pp.2208 - 2217 | - |
dc.relation.isPartOf | JOURNAL OF VIROLOGY | - |
dc.citation.title | JOURNAL OF VIROLOGY | - |
dc.citation.volume | 82 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 2208 | - |
dc.citation.endPage | 2217 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | REGULATORY FACTOR FAMILY | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTOR-9 | - |
dc.subject.keywordPlus | DOUBLE-STRANDED-RNA | - |
dc.subject.keywordPlus | RIG-I | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | MURINE GAMMAHERPESVIRUS-68 | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | IMMUNE-RECOGNITION | - |
dc.subject.keywordPlus | VIRUS INTERFERENCE | - |
dc.subject.keywordPlus | ANTIVIRAL RESPONSE | - |
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