Interferon-gamma (IFN-gamma): A possible prognostic marker for clearance of high-risk human papillomavirus (HPV)
DC Field | Value | Language |
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dc.contributor.author | Song, Seung-Hun | - |
dc.contributor.author | Lee, Jae-Kwan | - |
dc.contributor.author | Lee, Nak-Woo | - |
dc.contributor.author | Saw, Ho-Suk | - |
dc.contributor.author | Kang, Jae-Sung | - |
dc.contributor.author | Lee, Kyu-Wan | - |
dc.date.accessioned | 2021-09-09T10:56:38Z | - |
dc.date.available | 2021-09-09T10:56:38Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-03 | - |
dc.identifier.issn | 0090-8258 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124037 | - |
dc.description.abstract | Objectives. The goal of this study was to identify cytokines that may predict high-risk HPV clearance or persistence in untreated patients with mild dysplasia or less of the uterine cervix. Methods. A prospective analysis was performed on 57 patients who harbored high-risk HPV with histologically verified mild dysplasia or less between May 2005 and March 2006. All patients underwent follow-up evaluation at 12 months. Real-time PCR was used to quantify interferon-gamma (IFN-gamma), interleukin-10 (IL-10), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) transcripts. Hybrid Capture II testing was used to detect HPV DNA. Results. Among the 57 patients that were untreated with mild dysplasia, or less, 46 (80.7%) had no detectable HPV after 12 months of follow-up. Univariate analysis showed that a negative HPV test, of untreated mild dysplasia or less, occurred in 93.3% (28/30) of patients who were IFN-gamma-positive and in 66.7% (18/27) of patients who were IFN-gamma-negative (P=0.0109). Other factors such as age, lesion grade in the colposcopic biopsy, IL-10, IL-6, TNF-alpha, day of menstrual cycle, smoking, and use of oral contraceptives were not significantly associated with high-risk HPV negative or positive results after 12-months of follow-up in patients with untreated mild dysplasia or less. The multivariate logistic regression analysis showed that only IFN-gamma-positive results were significantly associated with clearance of high-risk HPV after 12 months of follow-up (OR: 8.26; 95% CI: 1.24-54.94). Conclusions. These results suggest that intralesional IFN-gamma may be a prognostic marker for clearance of high-risk HPV (C) 2007 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | SQUAMOUS INTRAEPITHELIAL LESIONS | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | CERVICAL-CARCINOMA | - |
dc.subject | TNF-ALPHA | - |
dc.subject | RNA EXPRESSION | - |
dc.subject | UTERINE CERVIX | - |
dc.subject | YOUNG-WOMEN | - |
dc.subject | VIRAL LOAD | - |
dc.subject | INFECTION | - |
dc.subject | CYTOKINE | - |
dc.title | Interferon-gamma (IFN-gamma): A possible prognostic marker for clearance of high-risk human papillomavirus (HPV) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Seung-Hun | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Kwan | - |
dc.contributor.affiliatedAuthor | Lee, Nak-Woo | - |
dc.identifier.doi | 10.1016/j.ygyno.2007.11.006 | - |
dc.identifier.scopusid | 2-s2.0-39249085187 | - |
dc.identifier.wosid | 000253697500016 | - |
dc.identifier.bibliographicCitation | GYNECOLOGIC ONCOLOGY, v.108, no.3, pp.543 - 548 | - |
dc.relation.isPartOf | GYNECOLOGIC ONCOLOGY | - |
dc.citation.title | GYNECOLOGIC ONCOLOGY | - |
dc.citation.volume | 108 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 543 | - |
dc.citation.endPage | 548 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.subject.keywordPlus | SQUAMOUS INTRAEPITHELIAL LESIONS | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | CERVICAL-CARCINOMA | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | RNA EXPRESSION | - |
dc.subject.keywordPlus | UTERINE CERVIX | - |
dc.subject.keywordPlus | YOUNG-WOMEN | - |
dc.subject.keywordPlus | VIRAL LOAD | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordAuthor | human papillomavirus (HPV) | - |
dc.subject.keywordAuthor | interferon-gamma (IFN-gamma) | - |
dc.subject.keywordAuthor | interleukin-10 (IL-10) | - |
dc.subject.keywordAuthor | interleukin-6 (IL-6) | - |
dc.subject.keywordAuthor | tumor necrosis factor-alpha (TNF-alpha) | - |
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