Photolytic control and infrared probing of amide I mode in the dipeptide backbone-caged with the 4,5-dimethoxy-2-nitrobenzyl group
DC Field | Value | Language |
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dc.contributor.author | Rhee, Hanju | - |
dc.contributor.author | Lee, Jang-Soo | - |
dc.contributor.author | Lee, Jihae | - |
dc.contributor.author | Joo, Cheonik | - |
dc.contributor.author | Han, Hogyu | - |
dc.contributor.author | Cho, Minhaeng | - |
dc.date.accessioned | 2021-09-09T11:06:20Z | - |
dc.date.available | 2021-09-09T11:06:20Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-02-21 | - |
dc.identifier.issn | 1520-6106 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124064 | - |
dc.description.abstract | Alanine dipeptide analog 1 backbone-caged with a photolabile linker, 4,5-dimethoxy-2-nitrobenzyl (DmNb), was synthesized. UV-pulse-induced photochemical reaction of 1 was monitored by Fourier transform IR absorption spectroscopy under a steady-state condition or in a fast-scan mode. Upon photolysis of 1, the amide I band is changed from a doublet to a singlet with concomitant line shape changes of several IR bands. The change of the amide I band is directly associated with the photocleavage of the covalent N-C bond connecting the backbone amide of 2 to DmNb. Therefore, IR spectroscopy is useful for directly probing the photocleavage of backbone-caged peptide 1 and the concurrent release of native peptide 2. In contrast, UV-vis spectroscopy probing the irradiation-induced structural change of the 2-nitrobenzyl moiety itself may not provide a clue directly relevant to the photocleavage of such N-C bond. Time-resolved IR spectra recorded in a fast-scan mode after pulsed UV irradiation of 1 reveal that such photocleavage occurs at least faster than a few seconds of our instrumental time resolution. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | PHOTOCHEMICAL-REACTION MECHANISMS | - |
dc.subject | VIBRATIONAL CIRCULAR-DICHROISM | - |
dc.subject | PEPTIDE CONFORMATIONAL DYNAMICS | - |
dc.subject | NANOSECOND TEMPERATURE-JUMP | - |
dc.subject | PROTEIN-FOLDING KINETICS | - |
dc.subject | N-ACETYLPROLINE AMIDE | - |
dc.subject | ALANINE DIPEPTIDE | - |
dc.subject | 2-NITROBENZYL COMPOUNDS | - |
dc.subject | FAST EVENTS | - |
dc.subject | PHOTOSWITCHABLE PEPTIDE | - |
dc.title | Photolytic control and infrared probing of amide I mode in the dipeptide backbone-caged with the 4,5-dimethoxy-2-nitrobenzyl group | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Hogyu | - |
dc.contributor.affiliatedAuthor | Cho, Minhaeng | - |
dc.identifier.doi | 10.1021/jp074776z | - |
dc.identifier.scopusid | 2-s2.0-39849105544 | - |
dc.identifier.wosid | 000253222300034 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHYSICAL CHEMISTRY B, v.112, no.7, pp.2128 - 2135 | - |
dc.relation.isPartOf | JOURNAL OF PHYSICAL CHEMISTRY B | - |
dc.citation.title | JOURNAL OF PHYSICAL CHEMISTRY B | - |
dc.citation.volume | 112 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2128 | - |
dc.citation.endPage | 2135 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.subject.keywordPlus | PHOTOCHEMICAL-REACTION MECHANISMS | - |
dc.subject.keywordPlus | VIBRATIONAL CIRCULAR-DICHROISM | - |
dc.subject.keywordPlus | PEPTIDE CONFORMATIONAL DYNAMICS | - |
dc.subject.keywordPlus | NANOSECOND TEMPERATURE-JUMP | - |
dc.subject.keywordPlus | PROTEIN-FOLDING KINETICS | - |
dc.subject.keywordPlus | N-ACETYLPROLINE AMIDE | - |
dc.subject.keywordPlus | ALANINE DIPEPTIDE | - |
dc.subject.keywordPlus | 2-NITROBENZYL COMPOUNDS | - |
dc.subject.keywordPlus | FAST EVENTS | - |
dc.subject.keywordPlus | PHOTOSWITCHABLE PEPTIDE | - |
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