Indeno[1,2-c]isoquinolines as enhancing agents on all-trans retinoic acid-mediated differentiation of human myeloid leukemia cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Oh, Sang Mi | - |
dc.contributor.author | Song, Ju Han | - |
dc.contributor.author | Cho, Daeho | - |
dc.contributor.author | Le, Quynh Manh | - |
dc.contributor.author | Lee, Suh-Hee | - |
dc.contributor.author | Chob, Won-Jea | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.accessioned | 2021-09-09T11:25:48Z | - |
dc.date.available | 2021-09-09T11:25:48Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-02-01 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124104 | - |
dc.description.abstract | Induction of differentiation is a new and promising approach to cancer therapy, well illustrated by the treatment of acute myeloid leukemia with all-trans retinoic acid (ATRA). Using combination of ATRA and chemotherapy, adverse effects such as retinoic acid syndrome have decreased, and long-term survival has improved. In this study, we demonstrated that the indeno[1,2-c]isoquinolines markedly enhanced differentiation of human myeloid leukemia HL-60 and NB4 cells when simultaneously combined with a low dose of ATRA. Of the tested compounds, 6-(4-methoxybenzyl)-2,11-dimethyl-6H, 11H-indeno[1,2-c]isoquinolin-5-one (IIQ-16), an indeno[1,2-c]isoquinoline derivative, showed the highest differentiation-enhancing activity via a pathway involved with protein kinase C, extracellular signal-regulated kinase, and e-Jun N-terminal kinase. The ability to enhance the differentiation potential of ATRA by IIQ-16 may improve outcomes in the therapy of acute promyelocytic leukemia. (c) 2007 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | TOPOISOMERASE-I INHIBITOR | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | PROMYELOCYTIC LEUKEMIA | - |
dc.subject | HL-60 | - |
dc.subject | INDUCTION | - |
dc.subject | EXPRESSION | - |
dc.subject | DOCKING | - |
dc.title | Indeno[1,2-c]isoquinolines as enhancing agents on all-trans retinoic acid-mediated differentiation of human myeloid leukemia cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1016/j.bmc.2007.10.086 | - |
dc.identifier.scopusid | 2-s2.0-38849090062 | - |
dc.identifier.wosid | 000253720100007 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY, v.16, no.3, pp.1125 - 1132 | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY | - |
dc.citation.volume | 16 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1125 | - |
dc.citation.endPage | 1132 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | TOPOISOMERASE-I INHIBITOR | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | PROMYELOCYTIC LEUKEMIA | - |
dc.subject.keywordPlus | HL-60 | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DOCKING | - |
dc.subject.keywordAuthor | All-trans retinoic acid | - |
dc.subject.keywordAuthor | Differentiation | - |
dc.subject.keywordAuthor | Indenoisoquinoline | - |
dc.subject.keywordAuthor | Leukemia | - |
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