Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Interleukin-10 and tumor necrosis factor-alpha polymorphisms in vascular access failure in patients on hemodialysis: Preliminary data in Korea

Authors
Sung, Su AhKo, Gang JeeJo, Sang KyungCho, Won YongKim, Hyoung KyuLee, So Young
Issue Date
2월-2008
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
polymorphism; single nucleotide; arteriovenous shunt; surgical; constriction; pathologic; renal dialysis
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.23, no.1, pp.89 - 93
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
23
Number
1
Start Page
89
End Page
93
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/124122
DOI
10.3346/jkms.2008.23.1.89
ISSN
1011-8934
Abstract
Neointimal hyperplasia causes vascular stenosis and subsequent thrombosis, which result in vascular access failure in patients undergoing hemodialysis. Interleukin-10 (IL-10) and tumour necrosis factor-alpha (TNF-alpha) are involved in this inflammatory process. The aim of this study was to investigate the relationship between vascular access failure and various inflammatory markers including the genetic polymorphisms of IL-10 and TNF-alpha. Seventy-five patients on hemodialysis with an arteriovenous fistula in place or an artificial graft (18 with vascular access failure and 82 without failure) and 98 healthy individuals were genotyped for IL-10 and TNF-alpha single nucleotide polymorphisms. Clinical and laboratory data including serum IL-10 and TNF-alpha levels were compared. Stimulated IL-10 levels, from in vitro incubation of blood with lipopolysaccharicle, were also obtained and compared. Female gender, hypoproteinemia, and hypertriglyceridemia were associated with vascular access failure. The basal TNF-alpha level was significantly higher in patients with access failure. The distribution of IL-10 and TNF-alpha genotype did not differ among patients with or without access failure. This study could not demonstrate a relationship between genetic polymorphisms and vascular access failure. However, an altered immune response an inflammation might contribute to vascular access failure.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE