Lack of association between the-759C/T polymorphism of the 5-HT2(C) receptor gene and olanzapine-induced weight gain among Korean schizophrenic patients
- Authors
- Park, Y. -M.; Cho, J. -H.; Kang, S. -G.; Choi, J. -E.; Lee, S. -H.; Kim, L.; Lee, H. -J.
- Issue Date
- 2월-2008
- Publisher
- BLACKWELL PUBLISHING
- Keywords
- 5HT2C receptor; olanzapine; polymorphism; schizophrenia; weight gain
- Citation
- JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, v.33, no.1, pp.55 - 60
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Volume
- 33
- Number
- 1
- Start Page
- 55
- End Page
- 60
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124146
- DOI
- 10.1111/j.1365-2710.2008.00872.x
- ISSN
- 0269-4727
- Abstract
- Background: Weight gain can be an adverse effect of antipsychotics that significantly affects long-term health and treatment compliance. Many reports have suggested that the 5-HT2C receptor gene (HTR2C) is related to appetite and eating behaviours associated with body weight change. We hypothesized that there was a relationship between the HTR2C -759C/T polymorphism and olanzapine-induced weight gain. Method: Seventy-nine Korean schizophrenic patients were examined. Their weight was measured before starting olanzapine and after long-term treatment for at least 3 months. We controlled the use of drugs other than olanzapine except benzodiazepines and anticholinergics. Genotyping for the HTR2C -759C/T polymorphism was performed on all participants. Result: We found that long-term treatment with olanzapine resulted in mean gains in weight and BMI of 5.2 kg and 1.93 kg/m(2), respectively. However, body weight changes from baseline to the study endpoint were not significantly associated with genotypes. The frequency of the T allele did not differ significantly between subjects with weight gains below and above a clinically significant cutoff, defined as 7% relative to baseline (chi(2) = 0.213, P = 0.445), indicating that the T allele had no protective effect against olanzapine-induced weight gain. Discussion and conclusion: The findings from this study do not support the presence of a relationship between the -759C/T polymorphism of the HTR2C gene and weight gain in Korean schizophrenic patients receiving olanzapine treatment.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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