Murine thymic stromal lymphopoietin promotes the differentiation of regulatory T cells from thymic CD4(+)CD8(-)CD25(-) naive cells in a dendritic cell-independent manner
DC Field | Value | Language |
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dc.contributor.author | Lee, June-Yong | - |
dc.contributor.author | Lim, Yu-Mi | - |
dc.contributor.author | Park, Min-Jung | - |
dc.contributor.author | Min, So-Youn | - |
dc.contributor.author | Cho, Mi-La | - |
dc.contributor.author | Sung, Young-Chul | - |
dc.contributor.author | Park, Se-Ho | - |
dc.contributor.author | Kim, Ho-Youn | - |
dc.contributor.author | Cho, Young-Gyu | - |
dc.date.accessioned | 2021-09-09T11:37:34Z | - |
dc.date.available | 2021-09-09T11:37:34Z | - |
dc.date.issued | 2008-02 | - |
dc.identifier.issn | 0818-9641 | - |
dc.identifier.issn | 1440-1711 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124156 | - |
dc.description.abstract | Human thymic stromal lymphopoietin (TSLP) activates dendritic cells (DCs), which promote the proliferation and differentiation of CD4(+) T cells. However, murine TSLP (mTSLP) can act directly on CD4(+) T cells and bring about their differentiation. We studied the role of mTSLP in the generation of CD4(+)CD25(+)FoxP3(+) T cells from thymocytes. mTSLP promoted the differentiation of CD4(+) single-positive thymocytes into CD4(+)CD25(+)FoxP3(+) T cells. Although we cannot exclude an effect of TSLP mediated through DCs due to co- stimulatory effects, mTSLP appears to act directly on thymocytes. T- cell receptor and TSLP receptor signaling act synergistically on thymocytes to generate CD4(+)CD25(+) FoxP3(+) T cells. mTSLP may play an important role in maintaining immune tolerance by promoting the conversion of thymocytes into natural regulatory T cells via escape from negative selection. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Murine thymic stromal lymphopoietin promotes the differentiation of regulatory T cells from thymic CD4(+)CD8(-)CD25(-) naive cells in a dendritic cell-independent manner | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1038/sj.icb.7100127 | - |
dc.identifier.scopusid | 2-s2.0-39749088250 | - |
dc.identifier.wosid | 000254087900018 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGY AND CELL BIOLOGY, v.86, no.2, pp 206 - 213 | - |
dc.citation.title | IMMUNOLOGY AND CELL BIOLOGY | - |
dc.citation.volume | 86 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 206 | - |
dc.citation.endPage | 213 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | HUMAN EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | ALLERGIC INFLAMMATION | - |
dc.subject.keywordPlus | SUPPRESSOR COMMITMENT | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | TSLP | - |
dc.subject.keywordPlus | INDUCE | - |
dc.subject.keywordPlus | INSTRUCTION | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.subject.keywordPlus | MEDIATED SIGNAL-TRANSDUCTION | - |
dc.subject.keywordAuthor | TSLP | - |
dc.subject.keywordAuthor | DCs | - |
dc.subject.keywordAuthor | Treg | - |
dc.subject.keywordAuthor | negative selection | - |
dc.subject.keywordAuthor | TCR | - |
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