Effect of postnatal treadmill exercise on c-Fos expression in the hippocampus of rat pups born from the alcohol-intoxicated mothers
- Authors
- Sim, Young-Je; Kim, Hong; Shin, Mal-Soon; Chang, Hyun-Kyung; Shin, Min-Chul; Ko, Il-Gyu; Kim, Ki-Jeong; Kim, Tea-Soo; Kim, Bo-Kyun; Rhim, Yong-Taek; Kim, Sangho; Park, Ho-Yoon; Yi, Jae-Woo; Lee, Sam-Jun; Kim, Chang-Ju
- Issue Date
- 2월-2008
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- maternal alcohol-intoxication; postnatal treadmill running; c-Fos expression; hippocampus; immunohistochemistry
- Citation
- BRAIN & DEVELOPMENT, v.30, no.2, pp.118 - 125
- Indexed
- SCIE
SCOPUS
- Journal Title
- BRAIN & DEVELOPMENT
- Volume
- 30
- Number
- 2
- Start Page
- 118
- End Page
- 125
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124185
- DOI
- 10.1016/j.braindev.2007.07.003
- ISSN
- 0387-7604
- Abstract
- Maternal alcohol-intoxication during pregnancy exerts detrimental effects on fetal development and is known to influence learning ability and memory capability by altering neuronal activity in the hippocampus. c-Fos expression represents neuronal activity and plays a crucial role in the brain development. Physical exercise is known to enhance neuronal plasticity and activity. In the present study, we investigated the influence of postnatal treadmill running on the c-Fos expression in the hippocampus of rat pups born from the alcohol-intoxicated mothers. The results obtained show that maternal alcohol-intoxication suppressed c-Fos expression in the hippocampus of rat pups and that postnatal treadmill exercise enhanced c-Fos expression in the hippocampus of these rat pups. The present study suggests that exercise should be considered as a therapeutic means of countering the effects of maternal alcohol-intoxication, and that it may provide a useful strategy for enhancing the neuronal activity of children born from the mothers who abuse alcohol during pregnancy. (C) 2007 Elsevier B.V. All rights reserved.
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Collections - College of Culture and Sports > Sport Science in Division of Global Sport Studies > 1. Journal Articles
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