Multifunctional magnetic gold nanocomposites: Human epithelial cancer detection via magnetic resonance imaging and localized synchronous therapy
- Authors
- Lee, Jaewon; Yang, Jaemoon; Ko, Hyunju; Oh, Seung Jae; Kang, Jinyoung; Son, Joo-Hriuk; Lee, Kwangyeol; Lee, Sang-Wha; Yoon, Ho-Geun; Suh, Jin-Suck; Huh, Yong-Min; Haam, SeungJoo
- Issue Date
- 24-1월-2008
- Publisher
- WILEY-V C H VERLAG GMBH
- Citation
- ADVANCED FUNCTIONAL MATERIALS, v.18, no.2, pp.258 - 264
- Indexed
- SCIE
SCOPUS
- Journal Title
- ADVANCED FUNCTIONAL MATERIALS
- Volume
- 18
- Number
- 2
- Start Page
- 258
- End Page
- 264
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124216
- DOI
- 10.1002/adfm.200700482
- ISSN
- 1616-301X
- Abstract
- Novel multifunctional magnetic gold nanocomposites (MGNCs) were synthesized for synchronous cancer therapy and diagnosis via magnetic resonance imaging (MRI). The MGNCs consist of magnetic kernels (aggregates of ultra-sensitive MnFe2O4 magnetic nanocrystals wrapped in polymer) as effective MR contrast agents and silica-gold nanocomposites as hyperthermal therapeutic agents. A therapeutic antibody, Erbitux (ERB), was conjugated for specific tumor cell targeting both to localize the near-IR laser beam and to image their events through MRI. ERB-conjugated MGNCs selectively recognize the target cancer cell lines. Fluorescence images and MRI analysis show that the MGNCs are effectively taken up by the cells. ERB-conjugated MGNCs have an excellent synchronous therapeutic efficacy as a result of the therapeutic antibody and near-IR laser-induced surface plasmon resonance. Consequently, MGNCs clearly demonstrate selective imaging and treatment of human epithelia] cancer simultaneously.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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