Brain cancer stem-like cell genesis from p53-deficient mouse astrocytes by oncogenic Ras
DC Field | Value | Language |
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dc.contributor.author | Lee, Joong-Seob | - |
dc.contributor.author | Gil, Jung-Eun | - |
dc.contributor.author | Kim, Jong-Hoon | - |
dc.contributor.author | Kim, Tae-Kyung | - |
dc.contributor.author | Jin, Xun | - |
dc.contributor.author | Oh, Se-Yeong | - |
dc.contributor.author | Sohn, Young-Woo | - |
dc.contributor.author | Jeon, Hye-Min | - |
dc.contributor.author | Park, Hyo-Jung | - |
dc.contributor.author | Park, Jong-Whi | - |
dc.contributor.author | Shin, Yong-Jae | - |
dc.contributor.author | Chung, Yong Gu | - |
dc.contributor.author | Lee, Jang-Bo | - |
dc.contributor.author | You, Seungkwon | - |
dc.contributor.author | Kim, Hyunggee | - |
dc.date.accessioned | 2021-09-09T11:59:09Z | - |
dc.date.available | 2021-09-09T11:59:09Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2008-01-18 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124222 | - |
dc.description.abstract | Here, we show that H-ras(v12) causes the p53-knockout mouse astrocytes (p53-/- astrocytes) to be transformed into brain cancer stem-like cells. H-ras(v12) triggers the p53-/- astrocytes to express a Nestin and a Cd133, which are expressed in normal and cancer neural stem cells. H-ras(V12) also induces the formation of a single cell-derived neurosphere under neural stem cell culture conditions. Furthermore, H-ras(_)(V12)overexpressing p53-/- astrocytes (p53-/-ast-H-ras(v12)) possess an in vitro self-renewal capacity, and are aberrantly differentiated into Tuj 1-positve neurons both in vitro and in vivo. Amongst a variety of Ras-mediated canonical signaling pathways, we demonstrated that the MEK/ERK signaling pathway is responsible for neurosphere formation in P53-deficient astrocytes, whereas the PI3K/AKT signaling pathway is involved in oncogenic transformation in these cells. These findings suggest that the activation of Ras signaling pathways promotes the generation of brain cancer stem-like cells from p53-deficient mouse astrocytes by changing cell fate and transforming cell properties. (c) 2007 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | GROWTH-FACTOR RECEPTOR | - |
dc.subject | NEURAL PROGENITORS | - |
dc.subject | HUMAN GLIOBLASTOMA | - |
dc.subject | GLIOMA | - |
dc.subject | AKT | - |
dc.subject | ACTIVATION | - |
dc.subject | TUMORS | - |
dc.subject | MICE | - |
dc.subject | EGF | - |
dc.title | Brain cancer stem-like cell genesis from p53-deficient mouse astrocytes by oncogenic Ras | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Hoon | - |
dc.contributor.affiliatedAuthor | Chung, Yong Gu | - |
dc.contributor.affiliatedAuthor | Lee, Jang-Bo | - |
dc.contributor.affiliatedAuthor | You, Seungkwon | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.11.005 | - |
dc.identifier.scopusid | 2-s2.0-36549077591 | - |
dc.identifier.wosid | 000251663100016 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.365, no.3, pp.496 - 502 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 365 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 496 | - |
dc.citation.endPage | 502 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | NEURAL PROGENITORS | - |
dc.subject.keywordPlus | HUMAN GLIOBLASTOMA | - |
dc.subject.keywordPlus | GLIOMA | - |
dc.subject.keywordPlus | AKT | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | EGF | - |
dc.subject.keywordAuthor | astrocyte | - |
dc.subject.keywordAuthor | brain cancer stem-like cells | - |
dc.subject.keywordAuthor | cell differentiation fate | - |
dc.subject.keywordAuthor | glioma | - |
dc.subject.keywordAuthor | H-ras | - |
dc.subject.keywordAuthor | p53 | - |
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