Comparison of prostate-specific antigen adjusted for transition zone volume versus prostate-specific antigen density in predicting prostate cancer by transrectal ultrasonography
DC Field | Value | Language |
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dc.contributor.author | Sung, DJ | - |
dc.contributor.author | Cho, SB | - |
dc.contributor.author | Kim, YH | - |
dc.contributor.author | Oh, YW | - |
dc.contributor.author | Lee, NJ | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Chung, KB | - |
dc.contributor.author | Moon, DG | - |
dc.date.accessioned | 2021-09-09T12:21:29Z | - |
dc.date.available | 2021-09-09T12:21:29Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2004-05 | - |
dc.identifier.issn | 0278-4297 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124327 | - |
dc.description.abstract | Objective. Prostate-specific antigen is an excellent tumor marker, but it is not specific for prostate cancer. We evaluated the efficacy of prostate-specific antigen adjusted for transition zone volume calculated by transrectal ultrasonography in predicting prostate cancer in men with intermediate prostate-specific antigen levels of 4.1 to 10.0 ng/mL compared with prostate-specific antigen density. Methods. Between June 1998 and December 2001, prostate-specific antigen adjusted for transition zone volume was obtained from 131 patients who underwent ultrasonographically guided biopsies and had prostate-specific antigen of 4.1 to 10.0 ng/mL. Prostate-specific antigen density was calculated by dividing total serum prostate-specific antigen by total prostate volume, and total serum prostate-specific antigen was divided by transition zone volume to yield prostate-specific antigen adjusted for transition zone volume. This was compared with prostate-specific antigen density via receiver operating characteristic curves. Results. Of 131 patients, 34 (26%) had prostate cancer, and 97 (74%) had benign prostatic hyperplasia on pathologic examination. Total prostate volume was correlated with transition zone volume (P < 001) Mean prostate-specific antigen adjusted for transition zone volume and prostate-specific antigen density were 0.71 +/- 0.25 and 0.27 +/- 0.09 ng (.) mL(-1) (.) mL(-1) in patients with prostate cancer and 0.32 +/- 0.09 and 0.16 +/- 0.05 ng (.) mL(-1) (.) mL(-1) in patients with benign prostatic hyperplasia. With a cutoff value of 0.35 ng (.) mL(-1) (.) mL(-1), prostate-specific antigen adjusted for transition zone volume had sensitivity of 82% and specificity of 84%. Receiver operating characteristic curve analysis showed that prostate-specific antigen adjusted for transition zone volume predicted biopsy outcome significantly better than prostate-specific antigen density (P < .05). Conclusions. Prostate-specific antigen adjusted for transition zone volume is more accurate than prostate-specific antigen density in distinguishing prostate cancer from benign prostatic hyperplasia in men with intermediate serum prostate-specific antigen of 4.1 to 10.0 ng/mL. Determination of transition zone volume by transrectal ultrasonography may be helpful for predicting the probability of positive biopsy results. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | ULTRASOUND | - |
dc.subject | ADENOCARCINOMA | - |
dc.subject | HYPERPLASIA | - |
dc.subject | CARCINOMA | - |
dc.subject | ENHANCE | - |
dc.subject | WEIGHT | - |
dc.subject | GLAND | - |
dc.subject | PSA | - |
dc.subject | MEN | - |
dc.title | Comparison of prostate-specific antigen adjusted for transition zone volume versus prostate-specific antigen density in predicting prostate cancer by transrectal ultrasonography | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sung, DJ | - |
dc.identifier.doi | 10.7863/jum.2004.23.5.615 | - |
dc.identifier.scopusid | 2-s2.0-2342578182 | - |
dc.identifier.wosid | 000221237600006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ULTRASOUND IN MEDICINE, v.23, no.5, pp.615 - 622 | - |
dc.relation.isPartOf | JOURNAL OF ULTRASOUND IN MEDICINE | - |
dc.citation.title | JOURNAL OF ULTRASOUND IN MEDICINE | - |
dc.citation.volume | 23 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 615 | - |
dc.citation.endPage | 622 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Acoustics | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Acoustics | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | ULTRASOUND | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | HYPERPLASIA | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | ENHANCE | - |
dc.subject.keywordPlus | WEIGHT | - |
dc.subject.keywordPlus | GLAND | - |
dc.subject.keywordPlus | PSA | - |
dc.subject.keywordPlus | MEN | - |
dc.subject.keywordAuthor | prostate | - |
dc.subject.keywordAuthor | prostate neoplasms | - |
dc.subject.keywordAuthor | ultrasonography | - |
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