Opioid antagonists: A review of their role in palliative care, focusing on use in opioid-related constipation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, YS | - |
dc.contributor.author | Billings, JA | - |
dc.date.accessioned | 2021-09-09T12:31:28Z | - |
dc.date.available | 2021-09-09T12:31:28Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2002-07 | - |
dc.identifier.issn | 0885-3924 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124383 | - |
dc.description.abstract | Opioid, antagonists have well-established indications in the reversal of life-threatening opioid toxicity, but also hold considerable promise for other applications in palliative care practice, particularly management of opioid-related constipation. We briefly review current understanding of opioid receptors, focusing on their complex role in gastrointestinal physiology. We summarize the pharmacology, conventional indications, and clinical usage of three major groups of opioid antagonists, including a promising new peripherally acting agent, methylnaltrexone, which is not commercially available. We suggest an an approach to administering opioid antagonists for reduction of life-threatening opioid toxicity in patients with pain. The literature on opioid-induced constipation and its treatment with opioid-antagonists is reviewed in detail. Finally, other potential uses of opioid antagonists in palliative care are described, especially strategies for reducing such opioid, side effects as nausea. and pruritus and for improving analgesia or reducing tolerance by concomitantly administrating both an opioid agonist and low dosages of an antagonist. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | INDUCED RESPIRATORY DEPRESSION | - |
dc.subject | CECAL TRANSIT-TIME | - |
dc.subject | QUATERNARY NARCOTIC-ANTAGONISTS | - |
dc.subject | PATIENT-CONTROLLED ANALGESIA | - |
dc.subject | MORPHINE-INDUCED INHIBITION | - |
dc.subject | OPIATE RECEPTOR-BINDING | - |
dc.subject | LOW-DOSE NALOXONE | - |
dc.subject | ORAL NALOXONE | - |
dc.subject | GASTROINTESTINAL TRANSIT | - |
dc.subject | EPIDURAL MORPHINE | - |
dc.title | Opioid antagonists: A review of their role in palliative care, focusing on use in opioid-related constipation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, YS | - |
dc.identifier.doi | 10.1016/S0885-3924(02)00424-4 | - |
dc.identifier.scopusid | 2-s2.0-0036056767 | - |
dc.identifier.wosid | 000177260200015 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, v.24, no.1, pp.71 - 90 | - |
dc.relation.isPartOf | JOURNAL OF PAIN AND SYMPTOM MANAGEMENT | - |
dc.citation.title | JOURNAL OF PAIN AND SYMPTOM MANAGEMENT | - |
dc.citation.volume | 24 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 71 | - |
dc.citation.endPage | 90 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Health Care Sciences & Services | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Health Care Sciences & Services | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | INDUCED RESPIRATORY DEPRESSION | - |
dc.subject.keywordPlus | CECAL TRANSIT-TIME | - |
dc.subject.keywordPlus | QUATERNARY NARCOTIC-ANTAGONISTS | - |
dc.subject.keywordPlus | PATIENT-CONTROLLED ANALGESIA | - |
dc.subject.keywordPlus | MORPHINE-INDUCED INHIBITION | - |
dc.subject.keywordPlus | OPIATE RECEPTOR-BINDING | - |
dc.subject.keywordPlus | LOW-DOSE NALOXONE | - |
dc.subject.keywordPlus | ORAL NALOXONE | - |
dc.subject.keywordPlus | GASTROINTESTINAL TRANSIT | - |
dc.subject.keywordPlus | EPIDURAL MORPHINE | - |
dc.subject.keywordAuthor | narcotic antagonists | - |
dc.subject.keywordAuthor | naloxone | - |
dc.subject.keywordAuthor | naltrexone | - |
dc.subject.keywordAuthor | nalmephene | - |
dc.subject.keywordAuthor | opioid-related disorders | - |
dc.subject.keywordAuthor | constipation | - |
dc.subject.keywordAuthor | gastrointestinal motility | - |
dc.subject.keywordAuthor | nausea/vomiting | - |
dc.subject.keywordAuthor | pruritus | - |
dc.subject.keywordAuthor | respiratory depression | - |
dc.subject.keywordAuthor | substace-related disorders | - |
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