The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: a nationwide multicentre prospective study in Korea
- Authors
- Kim, N.; Lee, S. W.; Choi, S. I.; Park, C. G.; Yang, C. H.; Kim, H. S.; Rew, J. S.; Moon, J. S.; Kim, S.; Park, S. H.; Jung, H. C.; Chung, I. S.
- Issue Date
- 15-1월-2008
- Publisher
- WILEY
- Citation
- ALIMENTARY PHARMACOLOGY & THERAPEUTICS, v.27, no.2, pp.173 - 185
- Indexed
- SCIE
SCOPUS
- Journal Title
- ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Volume
- 27
- Number
- 2
- Start Page
- 173
- End Page
- 185
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124439
- DOI
- 10.1111/j.1365-2036.2007.03561.x
- ISSN
- 0269-2813
- Abstract
- Background Prospective nationwide multicentre studies that have evaluated endoscopic findings and reflux symptoms using a well-designed questionnaire are very rare. Aim To compare the prevalence rates of and risk factors for erosive oesophagitis and non-erosive reflux disease (NERD) in the Korean population. Methods A gastroscopic examination was performed on 25 536 subjects who visited 40 Healthcare Centers for a health check-up. A gastro-oesophageal reflux questionnaire and multivariate analysis were used to determine the risk factors for erosive oesophagitis and NERD. Results 2019 (8%) and 996 subjects (4%) had erosive oesophagitis and non-erosive reflux disease, respectively; only 58% of subjects with erosive oesophagitis had reflux symptoms. Multivariate analysis showed that the risk factors for erosive oesophagitis and NERD differed, i.e. those of erosive oesophagitis were male, a Helicobacter pylori eradication history, alcohol, body mass index >= 25 and hiatal hernia. In contrast, the risk factors for NERD were female, age <40 and >= 60 vs. 40-59 years, body mass index <23 and a monthly income <$1000, glucose >= 126 mg/dL, smoking, a stooping posture at work and antibiotic usage. Conclusions prevalence rates of erosive oesophagitis and NERD were 8% and 4%, respectively, in Korean health check-up subjects. The risk factors for erosive oesophagitis and NERD were found to differ, which indicates that their underlying pathogeneses are distinct.
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