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Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: Design, synthesis, and biological evaluation

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dc.contributor.authorChun, Kwangwoo-
dc.contributor.authorPark, Song-Kyu-
dc.contributor.authorKim, Hwan Mook-
dc.contributor.authorChoi, Yongseok-
dc.contributor.authorKim, Myung-Hwa-
dc.contributor.authorPark, Chun-Ho-
dc.contributor.authorJoe, Bo-Young-
dc.contributor.authorChun, Tae Gyu-
dc.contributor.authorChoi, Hyun-Moo-
dc.contributor.authorLee, Hee-Yoon-
dc.contributor.authorHong, Sung Hee-
dc.contributor.authorKim, Myung Sook-
dc.contributor.authorNam, Ky-Youb-
dc.contributor.authorHan, Gyoonhee-
dc.date.accessioned2021-09-09T12:49:00Z-
dc.date.available2021-09-09T12:49:00Z-
dc.date.created2021-06-15-
dc.date.issued2008-01-01-
dc.identifier.issn0968-0896-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/124452-
dc.description.abstractA series of coumarin types MMP inhibitors were designed based on gelastatin hydroxamates (1) and evaluated for TACE, cellular TNF-alpha, and NO inhibitory activities. Among them, compounds 9b had potent inhibitory activities in enzymatic and cellular assays and good selectivity to MMP-2 and MMP-9. Further investigation of 9b will be carried out for its efficacy in RA animal model system. (c) 2007 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectNECROSIS-FACTOR-ALPHA-
dc.subjectCATALYTIC DOMAIN-
dc.subjectMETALLOPROTEINASE-
dc.subjectDISINTEGRIN-
dc.titleChromen-based TNF-alpha converting enzyme (TACE) inhibitors: Design, synthesis, and biological evaluation-
dc.typeArticle-
dc.contributor.affiliatedAuthorPark, Song-Kyu-
dc.contributor.affiliatedAuthorKim, Hwan Mook-
dc.contributor.affiliatedAuthorChoi, Yongseok-
dc.identifier.doi10.1016/j.bmc.2007.09.014-
dc.identifier.scopusid2-s2.0-38049028622-
dc.identifier.wosid000253345400054-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY, v.16, no.1, pp.530 - 535-
dc.relation.isPartOfBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.volume16-
dc.citation.number1-
dc.citation.startPage530-
dc.citation.endPage535-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusNECROSIS-FACTOR-ALPHA-
dc.subject.keywordPlusCATALYTIC DOMAIN-
dc.subject.keywordPlusMETALLOPROTEINASE-
dc.subject.keywordPlusDISINTEGRIN-
dc.subject.keywordAuthorTNF-alpha converting enzyme (TACE)-
dc.subject.keywordAuthormetalloproteinase-2 (MMP-2)-
dc.subject.keywordAuthormetalloproteinase-9 (MMP-9)-
dc.subject.keywordAuthorrheumatoid arthritis (RA)-
dc.subject.keywordAuthorgelastatin hydroxamates-
dc.subject.keywordAuthorcoumarin derivatives-
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