Effect of rifampin, an inducer of CYP3A and P-glycoprotein, on the pharmacokinetics of risperidone
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyoung-Ah | - |
dc.contributor.author | Park, Pil-Whan | - |
dc.contributor.author | Liu, Kwang-Hyeon | - |
dc.contributor.author | Kim, Kwon-Bok | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.contributor.author | Shin, Jae-Gook | - |
dc.contributor.author | Park, Ji-Young | - |
dc.date.accessioned | 2021-09-09T13:09:36Z | - |
dc.date.available | 2021-09-09T13:09:36Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2008-01 | - |
dc.identifier.issn | 0091-2700 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124534 | - |
dc.description.abstract | The authors studied the effect of rifampin, a dual inducer of CYP3A and P-glycoprotein, on the pharmacokinetics and pharmacodynamics of risperidone in humans. Ten healthy male subjects were treated daily for 7 days with 600 mg rifampin or with placebo. On day 6, a single dose of 1 mg risperidone was administered. Plasma risperidone and 9-hydroxyrisperidone concentrations were measured. Rifampin significantly decreased the mean area under the plasma concentration-time curve by 51% for risperidone. by 43% for 9-hydroxyrisperidone, and by 45% for the active moieties (risperidone + 9-hydroxyrisperidone). Rifampin also decreased the peak plasma concentration of risperidone by 38%, 9-hydroxyrisperidone by 46%, and the active moieties by 41%. The apparent oral clearance of risperidone approximately doubled after rifampin treatment. Thus, rifampin reduced the exposure to risperidone, probably because of a decrease in its bioavailability through the induction of CYP3A and probably P-glycoprotein. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.subject | PLASMA-CONCENTRATIONS | - |
dc.subject | DRUG-INTERACTIONS | - |
dc.subject | HUMAN HEPATOCYTES | - |
dc.subject | ACTIVE METABOLITE | - |
dc.subject | CYP2D6 GENOTYPES | - |
dc.subject | HEALTHY-SUBJECTS | - |
dc.subject | 9-HYDROXYRISPERIDONE | - |
dc.subject | PHARMACODYNAMICS | - |
dc.subject | IDENTIFICATION | - |
dc.subject | CARBAMAZEPINE | - |
dc.title | Effect of rifampin, an inducer of CYP3A and P-glycoprotein, on the pharmacokinetics of risperidone | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Heon-Jeong | - |
dc.contributor.affiliatedAuthor | Park, Ji-Young | - |
dc.identifier.doi | 10.1177/0091270007309888 | - |
dc.identifier.scopusid | 2-s2.0-37349104732 | - |
dc.identifier.wosid | 000252150200010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PHARMACOLOGY, v.48, no.1, pp.66 - 72 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PHARMACOLOGY | - |
dc.citation.title | JOURNAL OF CLINICAL PHARMACOLOGY | - |
dc.citation.volume | 48 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 66 | - |
dc.citation.endPage | 72 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | PLASMA-CONCENTRATIONS | - |
dc.subject.keywordPlus | DRUG-INTERACTIONS | - |
dc.subject.keywordPlus | HUMAN HEPATOCYTES | - |
dc.subject.keywordPlus | ACTIVE METABOLITE | - |
dc.subject.keywordPlus | CYP2D6 GENOTYPES | - |
dc.subject.keywordPlus | HEALTHY-SUBJECTS | - |
dc.subject.keywordPlus | 9-HYDROXYRISPERIDONE | - |
dc.subject.keywordPlus | PHARMACODYNAMICS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CARBAMAZEPINE | - |
dc.subject.keywordAuthor | rifampin | - |
dc.subject.keywordAuthor | risperidone | - |
dc.subject.keywordAuthor | 9-hydroxyrisperidone | - |
dc.subject.keywordAuthor | cytochrome P450 3A (CYP3A) | - |
dc.subject.keywordAuthor | P-glycoprotein | - |
dc.subject.keywordAuthor | drug interaction | - |
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