최근 12년간 발생한 자발성 세균성 복막염의 균주와 항생제 내성의 변화
DC Field | Value | Language |
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dc.contributor.author | 주문경 | - |
dc.contributor.author | 연종은 | - |
dc.contributor.author | 이순재 | - |
dc.contributor.author | 서상준 | - |
dc.contributor.author | 정영걸 | - |
dc.contributor.author | 김정한 | - |
dc.contributor.author | 김지훈 | - |
dc.contributor.author | 임형준 | - |
dc.contributor.author | 변관수 | - |
dc.date.accessioned | 2021-09-09T13:20:06Z | - |
dc.date.available | 2021-09-09T13:20:06Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1738-9364 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124562 | - |
dc.description.abstract | Background/Aims : Recently, the prognosis for spontaneous bacterial peritonitis (SBP) has improved; however, the causative microorganisms and antibiotic resistance rates are changing. We evaluated the changing pattern of causative agents and antibiotic resistance rates of SBP over a 12-year period. Methods : We retrospectively analyzed 113 patients who were diagnosed with SBP and in whom ascites cultures were positive between 1996 and 2007. The 12-year period was subdivided into 6-year terms (period A, 1996~2001; and period B, 2002~2007). Results : One hundred thirteen of 410 cases of SPB had positive ascites cultures. Thirty-seven cases were from period A and 76 cases were from period B. Hospital-acquired SBP was more common during period B. Gram negative microorganisms were isolated from 78% of SBP cases, and the most common microorganism was E.coli (60%). The resistance rates for ampicillin and ciprofloxacin were similar between the two periods, but resistance to cefotaxime was more frequent in period B (3% vs. 26%, p=0.002), and ESBL-producing E.coli was only cultured in period B (0% vs. 32%, p=0.002). Most of the initial antibiotics used were cefotaxime; carbapenem was used as a secondary antibiotic only in period B (0% vs. 55%, p=0.007). ESBL-producing microorganisms were the only predictor of in-hospital mortality based multivariate analysis (OR: 4.14, 95% CI: 1.09-15.07, p=0.037). Conclusions : No change in pattern of microorganisms in the ascites of patients with SBP was noted during the 12-year period under study, but there was a significant increase in the incidence of hospital-acquired SBP, resistance to cefotaxime, and ESBL-producing E.coli when comparing the outcomes of periods A and B. ESBL-producing microorganisms were the only predictor of in-hospital mortality. (Korean J Med 75:68-76, 2008) | - |
dc.language | Korean | - |
dc.language.iso | ko | - |
dc.publisher | 대한내과학회 | - |
dc.title | 최근 12년간 발생한 자발성 세균성 복막염의 균주와 항생제 내성의 변화 | - |
dc.title.alternative | Changing pattern of microorganisms and antibiotic resistance rate of spontaneous bacterial peritonitis: A 12-year experience | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 연종은 | - |
dc.contributor.affiliatedAuthor | 김지훈 | - |
dc.contributor.affiliatedAuthor | 임형준 | - |
dc.identifier.bibliographicCitation | 대한내과학회지, v.75, no.1, pp.68 - 76 | - |
dc.relation.isPartOf | 대한내과학회지 | - |
dc.citation.title | 대한내과학회지 | - |
dc.citation.volume | 75 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 68 | - |
dc.citation.endPage | 76 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001266401 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Liver cirrhosis | - |
dc.subject.keywordAuthor | Peritonitis | - |
dc.subject.keywordAuthor | Microorganism | - |
dc.subject.keywordAuthor | Drug Resistance | - |
dc.subject.keywordAuthor | Bacteria | - |
dc.subject.keywordAuthor | 간경변 | - |
dc.subject.keywordAuthor | 복막염 | - |
dc.subject.keywordAuthor | 원인 균주 | - |
dc.subject.keywordAuthor | 항균제 내성률 | - |
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