The Bone Morphogenesis Protein-2 (BMP-2) is Associated with Progression to Metastatic Disease in Gastric Cancer
DC Field | Value | Language |
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dc.contributor.author | 박용 | - |
dc.contributor.author | 김지원 | - |
dc.contributor.author | 김대식 | - |
dc.contributor.author | 김의배 | - |
dc.contributor.author | 박세종 | - |
dc.contributor.author | 박진용 | - |
dc.contributor.author | 최우석 | - |
dc.contributor.author | 송종규 | - |
dc.contributor.author | 서희연 | - |
dc.contributor.author | 오상철 | - |
dc.contributor.author | 김병수 | - |
dc.contributor.author | 박종재 | - |
dc.contributor.author | 김열홍 | - |
dc.contributor.author | 김준석 | - |
dc.date.accessioned | 2021-09-09T13:20:42Z | - |
dc.date.available | 2021-09-09T13:20:42Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124565 | - |
dc.description.abstract | Purpose: Bone Morphogenetic Proteins (BMPs) are members of the TGF-β superfamily and it has been demonstrated that BMPs enhance migration, invasion and metastasis. The purpose of this study was to identify the association between the serum BMP-2 level and the progression status of gastric cancer. Materials and Methods: Fifty-five patients with metastatic gastric cancer (metastatic disease group), six patients with early gastric cancer without lymph node metastasis (the EGC group), and ten healthy control subjects were enrolled in this study. The serum BMP-2 level was quantified by use of a commercially available ELISA kit. In EGC group patients and patients with metastatic disease, whole blood was obtained before endoscopic mucosal resection and before the commencement of a scheduled cycle of systemic chemotherapy, respectively. Results: No significant difference in the mean serum BMP-2 levels was observed between the control subjects and the EGC group patients (87.95 pg/ml for the control subjects and 84.50 pg/ml for the EGC group, p=1.0). However, the metastatic disease group patients had a significantly higher level of serum BMP (179.61 pg/ml) than the control subjects and EGC group patients (87.95 pg/ml for the control subjects and 84.50 pg/ml for the EGC group, p<0.0001). Moreover, the mean serum BMP-2 level from patients with a bone metastasis was significantly higher than the mean serum BMP-2 level from patients without a bone metastasis (204.73 pg/ml versus 173.33 pg/ml, p=0.021). Conclusions: BMP-2 seems to have a role in progression to metastatic disease in gastric cancer, especially in the late stage of tumorigenesis, including invasion and metastasis. BMP-2 may facilitate bone metastasis in gastric cancer. To confirm these findings, further studies are required with tissue specimens and the use of a cancer cell line. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 대한암학회 | - |
dc.title | The Bone Morphogenesis Protein-2 (BMP-2) is Associated with Progression to Metastatic Disease in Gastric Cancer | - |
dc.title.alternative | The Bone Morphogenesis Protein-2 (BMP-2) is Associated with Progression to Metastatic Disease in Gastric Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 오상철 | - |
dc.contributor.affiliatedAuthor | 김열홍 | - |
dc.identifier.bibliographicCitation | Cancer Research and Treatment, v.40, no.3, pp.127 - 132 | - |
dc.relation.isPartOf | Cancer Research and Treatment | - |
dc.citation.title | Cancer Research and Treatment | - |
dc.citation.volume | 40 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 127 | - |
dc.citation.endPage | 132 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001285477 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Bone morphogenesis protein-2 | - |
dc.subject.keywordAuthor | BMP-2 | - |
dc.subject.keywordAuthor | Stomach neoplasms | - |
dc.subject.keywordAuthor | Invasion | - |
dc.subject.keywordAuthor | Neoplasm metastasis | - |
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