Telmisartan과 Valsartan 투여가 제2형 당뇨병환자의 혈중 아디포넥틴과 동맥 경직도에 미치는 영향 - 예비 연구
DC Field | Value | Language |
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dc.contributor.author | 박수연 | - |
dc.contributor.author | 서지아 | - |
dc.contributor.author | 최경묵 | - |
dc.contributor.author | 백세현 | - |
dc.contributor.author | 최동섭 | - |
dc.contributor.author | 김난희 | - |
dc.contributor.author | 김신곤 | - |
dc.contributor.author | 박주리 | - |
dc.contributor.author | 이윤정 | - |
dc.contributor.author | 김희영 | - |
dc.date.accessioned | 2021-09-09T13:38:02Z | - |
dc.date.available | 2021-09-09T13:38:02Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124664 | - |
dc.description.abstract | Background: Telmisartan, used for the treatment of hypertension, has been shown to function as a partial agonist of peroxime proliferative activated receptor-ν(PPAR-ν). Theoretically, telmisartan which simulta- neously blocks the angiotensin II receptor and activates PPAR-ν should be more effective in improving atherosclerotic surrogate markers than angiotensin II receptor blockers alone. Therefore, this pilot study was designed to evaluate and compare the efficacy of telmisartan and valsartan on plasma adiponectin levels and pulse wave velocity as a marker of arterial stiffness in patients with type 2 diabetes. Methods: Thirty two patients with type 2 diabetes(mean duration 7.6 ± 5.1 years) taking oral hypoglycemic agents were randomly assigned to receive telmisartan or valsartan for 12 weeks.Results: Telmisartan and valsartan treatment significantly increased circulating adiponectin levels(P = 0.013 and P = 0.013, respectively) and reduced systolic(P = 0.001 and P = 0.002, respectively) and diastolic blood pressure(P = 0.001 and P < 0.001, respectively), and brachial-ankle PWV(P = 0.019 and P = 0.002, respectively), without significant differences between the two treatments. Before and after treatment, the fasting plasma glucose, interleukin-6, homeostasis model of assessment insulin resistance(HOMAIR) levels and lipid profile were unchanged in both treatment groups.Conclusion: Contrary to our expectation, telmisartan, even with its partial PPAR-ν activity, is not superior to valsartan in improving plasma adipocytokine levels and arterial stiffness in patients with type 2 diabetes. These data suggest that the partial PPAR-ν activity of telmisartan beyond valsartan may have less significant therapeutic implications than expected in treating patients with type 2 diabetes.(KOREAN DIABETES J 32:236-242, 2008) | - |
dc.language | Korean | - |
dc.language.iso | ko | - |
dc.publisher | 대한당뇨병학회 | - |
dc.title | Telmisartan과 Valsartan 투여가 제2형 당뇨병환자의 혈중 아디포넥틴과 동맥 경직도에 미치는 영향 - 예비 연구 | - |
dc.title.alternative | Effects of Telmisartan Compared with Valsartan on Plasma Adiponectin Levels and Arterial Stiffness in Patients with Type 2 Diabetes - A Pilot Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 서지아 | - |
dc.contributor.affiliatedAuthor | 최경묵 | - |
dc.contributor.affiliatedAuthor | 최동섭 | - |
dc.contributor.affiliatedAuthor | 김난희 | - |
dc.contributor.affiliatedAuthor | 김신곤 | - |
dc.identifier.bibliographicCitation | Diabetes and Metabolism Journal, v.32, no.3, pp.236 - 242 | - |
dc.relation.isPartOf | Diabetes and Metabolism Journal | - |
dc.citation.title | Diabetes and Metabolism Journal | - |
dc.citation.volume | 32 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 236 | - |
dc.citation.endPage | 242 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001250350 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Adiponectin | - |
dc.subject.keywordAuthor | Pulse wave velocity | - |
dc.subject.keywordAuthor | Telmisartan | - |
dc.subject.keywordAuthor | Type 2 diabetes | - |
dc.subject.keywordAuthor | Valsartan | - |
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