우울장애 환자에서 자살 시도와 트립토판 수산화 효소(Tryptophan Hydroxylase) A218C 유전자 다형성과의 관련성
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 심세훈 | - |
dc.contributor.author | 황보영 | - |
dc.contributor.author | 권영준 | - |
dc.contributor.author | 정희연 | - |
dc.contributor.author | 이분희 | - |
dc.contributor.author | 김용구 | - |
dc.date.accessioned | 2021-09-09T14:09:58Z | - |
dc.date.available | 2021-09-09T14:09:58Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1015-4817 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124822 | - |
dc.description.abstract | Objectives:Several lines of evidence suggest the serotonergic dysfunction involved in the biological susceptibility of suicide. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, plays a vital role in serotonin metabolism. In a case-control study, we investigated whether the TPH gene was a susceptible factor for suicidal behavior in depressive patients. Methods:The subjects were 218 depressed patients who attempted suicide and visited emergency rooms in multi-medical centers. One hundred thirty hospitalized non-suicidal depressed patients and the 161 normal controls were matched with the suicidal group. Individuals in all 3 groups were evaluated independently by a Structured Clinical Interview for the purpose of establishing a DSM-IV criteria diagnosis (SCID). The severity of depressive symptoms was evaluated using Hamilton depression rating scale (HDRS). Results:There was no significant difference in genotype distributions and allele frequencies of TPH intron 7 A218C polymorphisms among 3 groups. Furthermore, no significant difference in genotype counts and allele frequencies of the polymorphisms was found among lethal suicidal depressed patients, non-suicidal depressed patients and the normal controls. Conclusion:This study suggests that the A218C polymorphism of the TPH gene is unlikely to have a major effect on the susceptibility of suicidal behaviors in depressive patients. (J Korean Neuropsychiatr Assoc 2008;47(2):142-152) | - |
dc.language | Korean | - |
dc.language.iso | ko | - |
dc.publisher | 대한신경정신의학회 | - |
dc.title | 우울장애 환자에서 자살 시도와 트립토판 수산화 효소(Tryptophan Hydroxylase) A218C 유전자 다형성과의 관련성 | - |
dc.title.alternative | Association Between Suicide Attempts in Patients With Depressive Disorder and Tryptophan Hydroxylase A218C Polymorphism | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 김용구 | - |
dc.identifier.bibliographicCitation | 신경정신의학, v.47, no.2, pp.142 - 152 | - |
dc.relation.isPartOf | 신경정신의학 | - |
dc.citation.title | 신경정신의학 | - |
dc.citation.volume | 47 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 142 | - |
dc.citation.endPage | 152 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001254981 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Suicide· Tryptophan hydroxylase (TPH)· Depression· Asociation study. | - |
dc.subject.keywordAuthor | 자살·트립토판 수산화 효소·우울증·연합연구. | - |
dc.subject.keywordAuthor | Suicide· Tryptophan hydroxylase (TPH)· Depression· Asociation study. | - |
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