성인 골수 줄기세포의 조골세포로의 분화에서 유전자의 발현에 대한 연구Exploring upregulated genes during osteogenic differentiation of hMSCs
- Other Titles
- Exploring upregulated genes during osteogenic differentiation of hMSCs
- Authors
- 안세경; 임재석; 권종진; 이의석; 장현석
- Issue Date
- 2008
- Publisher
- 대한구강악안면외과학회
- Keywords
- Bone marrow mesenchymal stem cells; Osteogenic supplements; Suppression subtractive hybridization(SSH); IGFBP-2; HF1; Bone marrow mesenchymal stem cells; Osteogenic supplements; Suppression subtractive hybridization(SSH); IGFBP-2; HF1
- Citation
- 대한구강악안면외과학회지, v.34, no.1, pp.11 - 18
- Indexed
- KCI
- Journal Title
- 대한구강악안면외과학회지
- Volume
- 34
- Number
- 1
- Start Page
- 11
- End Page
- 18
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124833
- ISSN
- 2234-7550
- Abstract
- Human bone marrow mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tenden, muscle, and marrow stroma.
Cells that have the characteristics of human mesenchymal stem cells could be isolated from marrow aspirates of human and animals. This study was designed to identify and characterize genes specifically expressed by osteogenic supplements -treated cells by suppression subtractive hybridization(SSH) method.
The results were as follows:
1. 2 genes were upregulated genes in osteogenic diffeentiation of hMSCs, which is further proved by Northern blot analysis.
2. IGFBP-2 has been identified playing an important role in bone formation.
3. HF1 was also upregulated during osteogenic differentiation, but its role in bone formation is not clear yet
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.