Effect of Treadmill Training on ERK-Mediated Schwann Cell Proliferation and Axonal Regrowth in the Regenerating Sciatic Nerves
DC Field | Value | Language |
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dc.contributor.author | Tae-Beom Seo | - |
dc.contributor.author | Myung-Jin Oh | - |
dc.contributor.author | 윤진환 | - |
dc.contributor.author | 윤성진 | - |
dc.contributor.author | 박해찬 | - |
dc.contributor.author | Kyung-Hee Kang | - |
dc.contributor.author | 남궁욱 | - |
dc.date.accessioned | 2021-09-09T14:16:57Z | - |
dc.date.available | 2021-09-09T14:16:57Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1976-4391 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124860 | - |
dc.description.abstract | Proliferation of Schwann cells present in distal stump of injured sciatic nerve is a critical step for successful regeneration and this process is facilitated by physical activity. Extracellular signal-regulated kinase 1/2 (ERK1/2) regulates proliferation and differentiation of non-neuronal cells, but correlation between ERK1/2 activation and exercise remains mostly unknown. Here we show that phosphorylation of ERK1/2 (p-ERK1/2) mediates proliferation of Schwann cells at early stage after injury and treadmill training (TMT) is a key regulator for upreulation of p-ERK1/2 induction levels via activation of Schwann cells. Using primary cell culture techniques, we identified the positive effect of low- intensity TMT on neurite outgrowth of dorsal root ganglions (DRG) and proliferation of Schwann cells in normal rat. After sciatic nerve injury, TMT increased induction levels of GAP-43 protein, regeneration marker, according to the passage of TMT duration and sustained phosphorylation of ERK1/2 by 7 days after injury. Also transcription factor c-Jun related with MAPK was observed in injured nerve at 3 days post crush and largely upregulated by daily TMT performance. p-ERK1/2 protein expressed in Schwann cells was distally transported and accelerated by TMT at 1 and 3 days post crush. We further demonstrate that TMT promoted axonal regeneration 3 days after sciatic nerve injury, greatly suppressed by in vivo administration of ERK kinase inhibitor PD98059. Thus, the present data provide a new evidence that TMT-mediated enhancement of axonal regeneration involves dynamic regulation of Schwann cell activity by phosphorylation of ERK1/2. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 한국체육학회 | - |
dc.title | Effect of Treadmill Training on ERK-Mediated Schwann Cell Proliferation and Axonal Regrowth in the Regenerating Sciatic Nerves | - |
dc.title.alternative | Effect of Treadmill Training on ERK-Mediated Schwann Cell Proliferation and Axonal Regrowth in the Regenerating Sciatic Nerves | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 윤성진 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF HUMAN MOVEMENT SCIENCE, v.2, no.1, pp.63 - 77 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF HUMAN MOVEMENT SCIENCE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF HUMAN MOVEMENT SCIENCE | - |
dc.citation.volume | 2 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 63 | - |
dc.citation.endPage | 77 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001518892 | - |
dc.description.journalClass | 2 | - |
dc.subject.keywordAuthor | Sciatic nerve | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | Schwann cell | - |
dc.subject.keywordAuthor | proliferation | - |
dc.subject.keywordAuthor | treadmill training | - |
dc.subject.keywordAuthor | phosphorylation | - |
dc.subject.keywordAuthor | PD98059 | - |
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